{
  "abstract": "Gallstones (GS) affect 10–20% of adults around the world with a prevalence of around 40% in Chile. Most individuals with GS are asymptomatic, which may reflect underlying differences in disease severity and associated health risks. Few studies have comprehensively assessed factors associated with GS symptomatology. We conducted a cross-sectional analysis of baseline data from the Chile Biliary Longitudinal Study (Chile BiLS), a prospective cohort of middle-aged Chilean women with ultrasound-diagnosed GS. Symptomatic GS (sGS) was defined as self-report of ever having biliary colic or acute cholecystitis. Associations between sGS and personal and clinical characteristics, socioeconomic status, ultrasound characteristics, medication use, occupational pesticide exposure, and key lifestyle factors were evaluated using multivariable logistic regression. Among 4,328 women with gallstones, 40% had symptomatic gallstones (sGS). Compared to women with asymptomatic gallstones (aGS), those with sGS were younger, had lower educational attainment, reported more frequent and intense nonspecific gastrointestinal symptoms, and had a higher prevalence of several gallbladder ultrasound abnormalities ( P < 0.05). Current occupational pesticide exposure was positively associated with sGS (aOR: 2.26; 95% CI 1.26, 4.06). In this cross-sectional study of women with ultrasound-confirmed gallstones in the Araucanía region of Chile, sGS were associated with younger age, lower educational attainment, greater gastrointestinal symptom burden, several gallbladder ultrasound abnormalities, and current occupational pesticide exposure. These findings characterize differences between symptomatic and asymptomatic gallstone disease in this population and warrant confirmation in longitudinal studies, particularly for occupational pesticide exposure.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Michael Daniels"
    },
    {
      "name": "Rime Jebai"
    },
    {
      "name": "Ilona Argirion"
    },
    {
      "name": "Ruth M. Pfeiffer"
    },
    {
      "name": "Sandra Cortés"
    },
    {
      "name": "Vanessa Van De Wyngard"
    },
    {
      "name": "Michael Curry"
    },
    {
      "name": "Noldy Mardones"
    },
    {
      "name": "Allan Hildesheim"
    },
    {
      "name": "Paz Cook"
    },
    {
      "name": "Juan Carlos Araya"
    },
    {
      "name": "Catterina Ferreccio"
    },
    {
      "name": "Jill Koshiol"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/62n0jdd9j32sr.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-74592-3",
  "fulltext_url": null,
  "id": "62n0jdd9j32sr",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-74592-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Gallbladder and Bile Duct Disorders"
    ]
  ],
  "openalex": "W7223094997",
  "pdf_url": "https://www.nature.com/articles/s41598-026-74592-3_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/62n0jdd9j32sr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "10.1038/s41598-026-74592-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-74592-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Gallbladder and Bile Duct Disorders",
      "subfield": "general"
    }
  ],
  "title": "Cross-sectional associations with symptomatic gallstones among women in Chile",
  "title_text": "Cross-sectional associations with symptomatic gallstones among women in Chile",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/62n0jdd9j32sr",
  "venue": "Scientific Reports",
  "versions": []
}