{
  "abstract": "We assessed the antiviral activity of a synthetic GM-CSF active-center peptide against a number of RNA- and DNA-containing viruses, both enveloped and nonenveloped. We evaluated the antiviral activity in vitro and in vivo against parainfluenza virus type 3 (strain Vok) and adenovirus serotype 3 (strain 3/Voronezh/2174/82) in a continuous culture of human laryngeal carcinoma HEp-2 cells. Virucidal activity was evaluated against human adenovirus type 5, Coxsackievirus B3, Echovirus 30 virus, influenza virus A/Puerto Rico/8/34 (H1N1), human parainfluenza virus type 3, herpes simplex virus type 1, OC43 coronavirus, and human cytomegalovirus propagated in various permissive cell lines. The peptide exhibited a stronger prophylactic effect than the ZP2 peptide preparation and showed preferential activity against enveloped RNA viruses. We detected no cytotoxic effect of ZP2 on HEp-2 cells in vitro.",
  "abstract_shown": true,
  "affiliations": [
    "Federal Budgetary Institution of Science, «Federal Scientific Research Institute of Viral Infections «Virome»», Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Ekaterinburg 620030, Russia.",
    "Orenburg Federal Research Center of the Ural Branch of the Russian Academy of Sciences, Orenburg 460000, Russia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Aleksandr Zurochka"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariya Dobrynina"
    },
    {
      "affs": [
        0
      ],
      "name": "Vladimir Zurochka",
      "orcid": "0000-0001-8930-3742"
    },
    {
      "affs": [
        1
      ],
      "name": "Viktor Gritsenko",
      "orcid": "0000-0001-7151-6985"
    },
    {
      "affs": [
        0
      ],
      "name": "Aleksandr Semenov",
      "orcid": "0000-0003-3223-8219"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/62z3t27s2sp2h.bib",
  "cited_by": 0,
  "doi": "10.3390/v18101124",
  "fulltext_url": "https://europepmc.org/articles/PMC13709354",
  "id": "62z3t27s2sp2h",
  "issns": [
    "1999-4915"
  ],
  "landing_url": "https://europepmc.org/article/MED/42944044",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7221515754",
  "pdf_url": "https://europepmc.org/articles/PMC13709354?pdf=render",
  "pmcid": "PMC13709354",
  "pmid": "42944044",
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/62z3t27s2sp2h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42944044",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42944044"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "Antiviral Action Mechanisms of a Synthetic GM-CSF Active-Center Peptide.",
  "title_text": "Antiviral Action Mechanisms of a Synthetic GM-CSF Active-Center Peptide.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/62z3t27s2sp2h",
  "venue": "Viruses",
  "versions": []
}