{
  "abstract": "Background: Altered memory self-awareness is common in mild cognitive impairment (MCI), but its relationship to Alzheimer's disease (AD) pathology and progression remains unclear. Methods: Using 590 amnestic MCI ADNI participants, memory self-awareness was derived from participant-informant discrepancies on the memory subdomain of the Everyday Cognition questionnaire. Heightened awareness and unawareness subscores were calculated, and k-means clustering identified four phenotypes. Associations with cerebrospinal fluid (CSF) and positron emission tomography (PET) were examined, and clinical progression was assessed using Cox models. Results: Aware and Unaware groups showed lower CSF amyloid-B, and higher CSF phosphorylated tau and PET amyloid. The Unaware phenotype was associated with increased progression risk (hazard ratio 2.41, 95% CI 1.48-3.92), whereas the Worried Well phenotype showed reduced risk (hazard ratio 0.58, 95% CI 0.34-0.99). Conclusions: Multidimensional assessment of memory self-awareness identifies biologically and prognostically distinct subgroups within MCI and may improve risk stratification in prodromal AD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Massachusetts General Hospital, Harvard Medical School. Department of Computer Science and Mathematics, Bowdoin College."
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "N. Enbar-Salo"
    },
    {
      "name": "P. Palmer"
    },
    {
      "name": "C. Munro"
    },
    {
      "name": "M. A. Dubbelman"
    },
    {
      "name": "A. Aaronson"
    },
    {
      "name": "R. Nosheny"
    },
    {
      "name": "J. Gatchel"
    },
    {
      "name": "G. Marshall"
    },
    {
      "name": "P. Vannini"
    },
    {
      "name": "Alzheimer's Disease Neuroimaging Initiative"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/63227gswyfz41.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.03.26367187",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.11.03.26367187v1.full",
  "id": "63227gswyfz41",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.11.03.26367187v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.11.03.26367187v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/63227gswyfz41.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T00:21:02Z",
      "native_id": "10.64898/2026.11.03.26367187",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.11.03.26367187v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Memory Self-Awareness Phenotypes are Associated with Alzheimers Disease Biomarker Burden and Clinical Progression in Amnestic Mild Cognitive Impairment",
  "title_text": "Memory Self-Awareness Phenotypes are Associated with Alzheimers Disease Biomarker Burden and Clinical Progression in Amnestic Mild Cognitive Impairment",
  "type": "preprint",
  "updated_at": "2026-11-07T00:20:51Z",
  "url": "https://research.draconitic.com/paper/63227gswyfz41",
  "venue": "medRxiv",
  "versions": []
}