{
  "abstract": "Background: Rising coronary artery disease (CAD) in young adults calls for early risk stratification, yet the atherogenic index of plasma (AIP) has been understudied in patients aged ≤35 years. We therefore assessed its association with coronary lesion severity and major adverse cardiovascular events (MACE) in this cohort. Methods: This single-center retrospective study enrolled 948 patients aged 18–35 years with angiographically confirmed CAD. Greater coronary lesion severity was defined as a Gensini score > 40. The association between AIP and MACE was explored. Results: During a median follow-up of 60 months, MACE occurred in 287 patients. After full adjustment, AIP as a continuous variable was independently associated with greater coronary lesion severity (OR = 1.761; 95% CI: 1.052–2.948; p = 0.031). Regarding prognosis, when AIP was dichotomized at 0.4, it was independently associated with MACE (HR = 1.350; 95% CI: 1.060–1.721; p = 0.015) in the fully adjusted model, whereas continuous AIP did not retain significance. Restricted cubic spline analysis suggested a possible U-shaped dose–response relationship between AIP and MACE (overall p < 0.001, nonlinear p = 0.051). Subgroup analyses showed that the association of AIP with MACE was generally consistent across all examined strata, with no significant interactions (all p for interaction >0.05). Conclusions: AIP was independently associated with greater coronary lesion severity and MACE in young CAD patients (≤35 years). These findings support AIP as a practical tool not only for early risk stratification but also for guiding intensive lipid-lowering therapy in this distinct population.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China",
    "Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing 100029, China",
    "Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, No. 2, Anzhen Road, Chaoyang District, Beijing 100029, China",
    "Beijing Anding Hospital, Capital Medical University, Beijing 100088, China",
    "School of Public Health, Capital Medical University, Beijing 100069, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jiayin Sun",
      "orcid": "0000-0002-6961-3118"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiayin Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Yuning Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Fei Zhao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wei Han"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yujie Zhou"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dongmei Shi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/63cf9ryxx1cwy.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208092",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706528/?tool=EBI",
  "id": "63cf9ryxx1cwy",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8092",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7222970385",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706528/pdf/?tool=EBI",
  "pmcid": "PMC13706528",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/63cf9ryxx1cwy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15208092",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8092"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13706528",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706528"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Prognostic Value of the Atherogenic Index of Plasma for Severity and Cardiovascular Outcomes in Young Patients (≤35 Years) with Coronary Artery Disease: A Retrospective Study",
  "title_text": "Prognostic Value of the Atherogenic Index of Plasma for Severity and Cardiovascular Outcomes in Young Patients (≤35 Years) with Coronary Artery Disease: A Retrospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/63cf9ryxx1cwy",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}