{
  "abstract": "Background: Diabetic Neuropathy (DN) is a prevalent complication of diabetes linked to chronic inflammation. Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are key cytokines implicated in DN pathogenesis. This study investigates the association of IL6 and IL10 gene polymorphisms and serum levels with DN in the Bangladeshi population. Materials and methods: A case-control study was conducted with 225 participants: diabetic patients with DN (n = 75), diabetic patients without DN (n = 75), and healthy controls (n = 75). Genomic DNA was extracted for genotyping IL-6 (rs1800796) and IL-10 (rs1800896) SNPs via PCR. Serum cytokine levels were measured using ELISA. Results: Serum IL-6 levels were significantly higher in the DN group than in the other study groups (p < 0.0001), with the highest levels observed among individuals with the IL-6 rs1800796 CC genotype. In unadjusted analyses, the IL-6 CC genotype was associated with increased odds of DN compared with healthy controls (OR = 4.813, 95% CI: 1.752–13.85, p = 0.0040), as was the IL-10 GG genotype (OR = 2.679, 95% CI: 1.000–6.751, p = 0.0373). However, neither IL-6 nor IL-10 genotype remained independently associated with DN after multivariable adjustment. Serum IL-10 levels did not differ significantly among the study groups (p = 0.0948). Combined genotype analyses showed several nominal associations, although these findings were exploratory. Serum IL-6 showed promising discriminatory ability in distinguishing patients with DN from the other study groups, whereas IL-10 demonstrated limited discriminatory performance. Conclusion: These findings support further investigation of serum IL-6 as a potential candidate biomarker for diabetic neuropathy, whereas the independent contribution of the investigated IL-6 and IL-10 polymorphisms remains uncertain. Larger prospective studies with independent external validation are required before clinical application can be considered.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.",
    "Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh."
  ],
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    {
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        0
      ],
      "name": "Rajib Das"
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    {
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        0
      ],
      "name": "Sheikh Zahir Raihan",
      "orcid": "0000-0002-7872-0177"
    },
    {
      "affs": [
        0
      ],
      "name": "Shyamjit Paul"
    },
    {
      "affs": [
        1
      ],
      "name": "Mohammad Shamsul Arefin Patwary"
    },
    {
      "affs": [
        0
      ],
      "name": "Abul Kalam Azad Chowdhury"
    }
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  "bibtex": "https://research.draconitic.com/paper/63gt6etaqmxcg.bib",
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  "doi": "10.1371/journal.pone.0360933",
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  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
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  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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  "pdf_url": "https://europepmc.org/articles/PMC13690206?pdf=render",
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  "pmid": "42911932",
  "published": "2026-10-22",
  "publisher": "Public Library of Science",
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  "title": "Association of IL-6 and IL-10 serum levels with genetic variants in diabetic neuropathy: Clinical findings from a Bangladeshi patient cohort",
  "title_text": "Association of IL-6 and IL-10 serum levels with genetic variants in diabetic neuropathy: Clinical findings from a Bangladeshi patient cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
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