{
  "abstract": "Background\n\nAuditory input is known to modulate the perception of pain, yet the reciprocal influence, how pain affects auditory processing, remains less well understood. We investigated how continuous tonic pain dynamically alters auditory cortical responses in humans.Methods\n\nUsing a three-stimulus auditory oddball paradigm combined with EEG, we recorded event-related potentials (ERPs) while participants experienced thermal stimulation under three conditions: baseline, non-painful warmth, and pain. We examined multiple stages of auditory processing, including early sensory encoding (N1, P2), automatic deviance detection (MMN), and attentional reorienting (P3a).Results\n\nTonic pain modulated auditory ERPs in a stage- and component-specific manner. Compared to baseline and warm conditions, pain was associated with enhanced P2 responses to distractors and reduced MMN and P3a amplitudes, although no statistically significant differences in behavioural performance were observed. This pattern suggests enhanced early salience detection alongside reduced pre-attentive deviance detection and involuntary attentional shifts under pain. The warm condition selectively modulated N1 amplitude, indicating that some effects may be related to the affective and attentional demands of pain rather than somatosensory stimulation per se.Conclusions\n\nContinuous tonic pain is associated with selective modulation of auditory processing, characterized by enhanced early sensory responsiveness and reduced higher-order attentional engagement. This biphasic neural pattern, observed in the absence of measurable behavioural differences, is consistent with predictive coding and salience network accounts of pain-attention interactions and highlights the sensitivity of ERPs for detecting pain-related neural reweighting. The absence of statistically significant behavioural effects should be interpreted with caution and may reflect relatively subtle or context-dependent influences of pain under the present task conditions.Significance statement\n\nThis study is among the first to systematically examine how experimentally induced tonic pain modulates distinct stages of auditory processing in healthy individuals using high-resolution ERPs, with a task design and hypothesis framework capable of teasing apart the cognitive mechanisms underlying these changes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head & Neck Surgery, McGill University, Montreal, Quebec, Canada.",
    "International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Quebec, Canada.",
    "Center for Research on Brain, Language and Music (CRBLM), Montreal, Quebec, Canada.",
    "Department of Psychology, University of Montreal, Montreal, Quebec, Canada.",
    "Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, Quebec, Canada.",
    "Institute of Biology, Leipzig University, Leipzig, Germany.",
    "Département de Stomatologie, Université de Montréal, Montréal, Quebec, Canada.",
    "Centre de Recherche de L'institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Alexandre Lehmann"
    },
    {
      "affs": [
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Marc Schönwiesner"
    },
    {
      "affs": [
        3,
        4,
        6,
        7
      ],
      "name": "Pierre Rainville"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/63hff2ay2r8tn.bib",
  "cited_by": 0,
  "doi": "10.1002/ejp.70405",
  "fulltext_url": "https://europepmc.org/articles/PMC13651782",
  "id": "63hff2ay2r8tn",
  "issns": [
    "1090-3801",
    "1532-2149"
  ],
  "landing_url": "https://europepmc.org/article/MED/42853237",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Neuroscience and Music Perception"
    ]
  ],
  "openalex": "W7221129538",
  "pdf_url": "https://europepmc.org/articles/PMC13651782?pdf=render",
  "pmcid": "PMC13651782",
  "pmid": "42853237",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/63hff2ay2r8tn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42853237",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42853237"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Neuroscience and Music Perception",
      "subfield": "neuroscience"
    }
  ],
  "title": "Pain Enhances the Auditory P2 but Attenuates Mismatch Response and P3a.",
  "title_text": "Pain Enhances the Auditory P2 but Attenuates Mismatch Response and P3a.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/63hff2ay2r8tn",
  "venue": "European journal of pain (London, England)",
  "versions": []
}