{
  "abstract": "Adaptive modulation of physiological traits in response to dietary fluctuations is essential for organismal fitness and is governed by complex gene-diet interactions that remain mechanistically unexplored. Here, we identify the conserved mTORC2 component RICTOR as a critical regulator of dietary plasticity in Caenorhabditis elegans. Loss of rict-1/RICTOR confers enhanced osmotic stress tolerance and longevity on vitamin B12-rich bacterial diets containing optimal methionine. These adaptations require two B12-dependent enzymes: methionine synthase (METR-1), functioning in the one-carbon cycle (Met-C), and methylmalonyl-CoA mutase (MMCM-1), a mitochondrial enzyme essential for propionate catabolism which generates succinyl-CoA, and via the TCA cycle, succinate. Elevated succinate induces mitochondrial fragmentation, activating mitophagy that is indispensable for the stress resilience and longevity of rict-1 mutant worms. This host Met-C-mitophagy axis is tuned by microbial inputs, constituting an interspecies interaction. Early-life fragmentation potentiates sustained mitophagy into late adulthood, preserving tubular mitochondria as the rict-1 mutant worms age, unlike wild-type worms. Thus, RICTOR restrains host sensitivity to microbe-derived metabolite fluctuations through organellar quality control, regulating lifespan.",
  "abstract_shown": true,
  "affiliations": [
    "Molecular Aging Laboratory, National Institute of Immunology, Delhi, India.",
    "CSIR-Institute of Genomics and Integrative Biology, Delhi, India.",
    "Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.",
    "Molecular Aging Laboratory, National Institute of Immunology, Delhi, India. arnab@nii.ac.in."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Simran Motwani"
    },
    {
      "affs": [
        0
      ],
      "name": "Somya Bhandari"
    },
    {
      "affs": [
        1
      ],
      "name": "Shivani Chitkara"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Rajat Ujjainiya"
    },
    {
      "affs": [
        0
      ],
      "name": "Prerona Ghosh"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Shantanu Sengupta",
      "orcid": "0000-0001-8461-0735"
    },
    {
      "affs": [
        3
      ],
      "name": "Arnab Mukhopadhyay",
      "orcid": "0000-0002-5266-7849"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/63k0b1s480fx8.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77722-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13724747",
  "id": "63k0b1s480fx8",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42967947",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7212967520",
  "pdf_url": "https://europepmc.org/articles/PMC13724747?pdf=render",
  "pmcid": "PMC13724747",
  "pmid": "42967947",
  "published": "2026-09-14",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/63k0b1s480fx8.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967947",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967947"
    },
    {
      "first_seen": "2026-11-04T12:23:16Z",
      "native_id": "PMC13724747",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77722-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "RICTOR regulates an interspecies crosstalk that influences longevity through a methionine cycle-mitophagy axis.",
  "title_text": "RICTOR regulates an interspecies crosstalk that influences longevity through a methionine cycle-mitophagy axis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:09Z",
  "url": "https://research.draconitic.com/paper/63k0b1s480fx8",
  "venue": "Nature communications",
  "versions": []
}