{
  "abstract": "Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is recognized as a core pathological process underlying vascular calcification (VC). The inflammatory response contributes to the development of phenotypic switch, yet there is a lack of therapeutic strategies targeting this process. In the current study, we first identified that inflammatory factors are associated with the osteogenic differentiation of VSMCs, and Interleukin-1β (IL-1β) might be a key triggering mediator. Furthermore, elevated levels of IL-1β were observed in the calcified arteries of both VC patients and mice, and this increase was positively correlated with the severity of calcification. In vivo, treatment with the IL-1β pharmacological inhibition Canakinumab alleviated calcification and osteogenic conversion in the aortas of CKD mice. In vitro, overexpression of IL-1β exacerbated calcification and osteogenic differentiation by promoting inflammation in VSMCs, emphasizing the central role of pro-inflammatory factors. Mechanistically, HMGA1 was predicted to be a potential transcription factor of IL-1β. Specifically, HMGA1 directly promoted the expression of IL-1β by binding to its promoter region. Moreover, IL-1β inhibition nullified the pro-calcific effect of HMGA1 on VSMCs calcification and osteogenic differentiation, whereas IL-1β overexpression abolished the protective effect of HMGA1 silence. Finally, VSMC-specific HMGA1 deficiency in mice attenuated CKD-induced aorta calcification. Collectively, our findings reveal a novel transcriptional regulatory mechanism governing IL-1β expression, highlighting the HMGA1/IL-1β axis as a promising therapeutic target for VC in CKD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.",
    "Hebei Clinical Research Center for Chronic Kidney Disease, Shijiazhuang, China.",
    "Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Shijiazhuang, China.",
    "Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. 46400262@hebmu.edu.cn.",
    "Hebei Clinical Research Center for Chronic Kidney Disease, Shijiazhuang, China. 46400262@hebmu.edu.cn.",
    "Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Shijiazhuang, China. 46400262@hebmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
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        0,
        1,
        2
      ],
      "name": "Binhong Yang",
      "orcid": "0009-0007-3702-4945"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Meijuan Cheng",
      "orcid": "0000-0002-4376-5017"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jingjing Jin",
      "orcid": "0000-0002-7666-2858"
    },
    {
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        1,
        2
      ],
      "name": "Kaixing Yan"
    },
    {
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        1,
        2
      ],
      "name": "Haoqi Sun"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Xinyue Yang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yunhui Wu"
    },
    {
      "affs": [
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        1,
        2
      ],
      "name": "Qi An"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dongxue Zhang"
    },
    {
      "affs": [
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        1,
        2
      ],
      "name": "Lixin Chang"
    },
    {
      "affs": [
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        1,
        2
      ],
      "name": "Shenglei Zhang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yaling Bai"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Jinsheng Xu",
      "orcid": "0000-0001-7634-2232"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/63mrd9jd7zpee.bib",
  "cited_by": 0,
  "doi": "10.1038/s41420-026-03271-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13720042",
  "id": "63mrd9jd7zpee",
  "issns": [
    "2058-7716"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957632",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "Article"
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      "2727|Parathyroid Disorders and Treatments"
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  "pdf_url": "https://europepmc.org/articles/PMC13720042?pdf=render",
  "pmcid": "PMC13720042",
  "pmid": "42957632",
  "published": "2026-08-04",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/63mrd9jd7zpee.ris",
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  "title": "HMGA1 accelerates vascular smooth muscle cell osteogenic phenotype transdifferentiation by elevating pro-inflammatory cytokine IL-1β transcription in chronic kidney disease.",
  "title_text": "HMGA1 accelerates vascular smooth muscle cell osteogenic phenotype transdifferentiation by elevating pro-inflammatory cytokine IL-1β transcription in chronic kidney disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:00Z",
  "url": "https://research.draconitic.com/paper/63mrd9jd7zpee",
  "venue": "Cell death discovery",
  "versions": []
}