{
  "abstract": "The incidence of melanoma is substantially lower in Asians than in Caucasians. This study retrospectively analyzed 355 patients in Xinjiang, China, to delineate the clinicopathological features and prognosis of melanoma in this region. The median overall survival (OS) and disease-free survival (DFS) were 78.0 and 46.0 months with 1-, 3-, and 5-year OS/DFS rates of 83.3%/68.3%/57.0% and 80.4%/59.5%/43.4%, respectively. Multivariate analysis identified advanced AJCC stage and elevated LDH as independent predictors of poorer OS. For DFS, AJCC stage, presence of metastasis, elevated LDH, and aCCI predicted worse outcomes, while adjuvant therapy was protective. Crucially, subtype-specific determinants emerged: aCCI independently predicted OS (HR = 18.42, P = 0.005) and DFS (HR = 4.91, P = 0.019) in CM, while higher BMI was associated with poorer DFS in AM (HR = 3.58, P = 0.019). These findings underscore the need for subtype-aware clinical management in this region.",
  "abstract_shown": true,
  "affiliations": [
    "Xinjiang Medical University, Urumqi, Xinjiang, China",
    "Department of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China",
    "Xinjiang Key Laboratory of Dermatology Research, Urumqi, Xinjiang, China",
    "Xinjiang Clinical Research Center for Dermatology and Venereology, Urumqi, Xinjiang, China",
    "Department of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China",
    "Department of Medical Research and Translational Management, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Caoying Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yongting Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Chun Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Yaoyuan Shen"
    },
    {
      "affs": [
        4
      ],
      "name": "Maimaitili Buheliqimu"
    },
    {
      "affs": [
        5
      ],
      "name": "Mahan Yeledan"
    },
    {
      "name": "Yuan Ding"
    },
    {
      "name": "Xiaojing Kang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/641hwa991t4xh.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357383",
  "fulltext_url": null,
  "id": "641hwa991t4xh",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357383",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cutaneous Melanoma Detection and Management"
    ],
    [
      "plos",
      "/Medicine and health sciences/Dermatology/Skin neoplasms/Malignant skin neoplasms/Cutaneous melanoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Prognosis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Epidemiology/Medical risk factors/Cancer risk factors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Basic cancer research/Metastasis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer risk factors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Melanoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Melanoma/CNS melanoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Melanoma/Cutaneous melanoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Skin neoplasms/Malignant skin neoplasms/Cutaneous melanoma"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Metastasis"
    ],
    [
      "plos",
      "/People and places/Geographical locations/Asia/China"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Statistics/Statistical methods/Multivariate analysis"
    ],
    [
      "plos",
      "/Research and analysis methods/Mathematical and statistical techniques/Statistical methods/Multivariate analysis"
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  "openalex": "W7212078442",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357383&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/641hwa991t4xh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0357383",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0357383"
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  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China",
  "title_text": "Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/641hwa991t4xh",
  "venue": "PLOS One",
  "versions": []
}