{
  "abstract": "Circulating microRNAs (miRNAs) are promising biomarkers of cardiovascular disease (CVD) and three-point major adverse cardiovascular events (3P-MACE): CVD death, non-fatal myocardial infarction (MI), and non-fatal stroke. The associations between plasma miRNA levels and 3P-MACE in a prospective cohort from an epidemiological study were evaluated. This nested case–control study included 479 participants: 166 cases with 3P-MACE and 313 controls matched individually for sex, exact baseline age, and region of residence. Median follow-up was 10.4 years [7.0; 11.7]. Total RNA was isolated from EDTA plasma using the miRNeasy Serum/Plasma Advanced Kit. Libraries were prepared with the QIAseq miRNA UDI Library Kit and sequenced on a NextSeq 550 (1 × 75 bp). After adjustment for six and twelve preanalytical and clinical covariates, eleven and five differentially expressed (DE) miRNAs retained significant associations with 3P-MACE or CVD death, respectively. Although these findings support plasma miRNA profiles as potential MACE biomarkers, all DE miRNAs remain exploratory. Further studies in larger independent populations with cross-validation are required before integration with traditional risk markers to predict future MACE.",
  "abstract_shown": true,
  "affiliations": [
    "National Medical Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Petroverigsky per. 10, Bld. 3, 101000 Moscow, Russia",
    "Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 1-73, Leninskie Gory, 119991 Moscow, Russia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna V. Kiseleva",
      "orcid": "0000-0003-4765-8021"
    },
    {
      "affs": [
        0
      ],
      "name": "Evgeniia A. Sotnikova"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Anastasia A. Zharikova",
      "orcid": "0000-0003-0723-0493"
    },
    {
      "affs": [
        0
      ],
      "name": "Vladimir A. Kutsenko",
      "orcid": "0000-0001-9844-3122"
    },
    {
      "affs": [
        0
      ],
      "name": "Asiia E. Imaeva"
    },
    {
      "affs": [
        0
      ],
      "name": "Yulia A. Balanova",
      "orcid": "0000-0001-8011-2798"
    },
    {
      "affs": [
        0
      ],
      "name": "Anna V. Kapustina"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuri V. Vyatkin"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria S. Pokrovskaya",
      "orcid": "0000-0001-6985-7131"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandra I. Ershova"
    },
    {
      "affs": [
        0
      ],
      "name": "Svetlana A. Shalnova"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexey N. Meshkov",
      "orcid": "0000-0001-5989-6233"
    },
    {
      "affs": [
        0
      ],
      "name": "Oxana M. Drapkina",
      "orcid": "0000-0003-0323-2635"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/646nbjph9hxt1.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209221",
  "fulltext_url": "https://europepmc.org/articles/PMC13705324",
  "id": "646nbjph9hxt1",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9221",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7222914630",
  "pdf_url": "https://europepmc.org/articles/PMC13705324?pdf=render",
  "pmcid": "PMC13705324",
  "pmid": "42941991",
  "published": "2026-10-17",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/646nbjph9hxt1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209221",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9221"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42941991",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941991"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "Association Between Plasma microRNA Levels and Major Adverse Cardiovascular Events in Participants from an Epidemiological Cohort",
  "title_text": "Association Between Plasma microRNA Levels and Major Adverse Cardiovascular Events in Participants from an Epidemiological Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/646nbjph9hxt1",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}