{
  "abstract": "Primary pulmonary mucoepidermoid carcinoma(PMEC) is a rare salivary gland-type malignancy, accounting for fewer than 0.2% of all primary lung tumors. We report herein a 61-year-old male patient with PMEC who was admitted for a space-occupying lesion in the left upper lobe and had a 20-year smoking history. Contrast-enhanced chest CT and positron emission tomography-computed tomography (PET-CT) revealed a central space-occupying lesion in the left hilum with distal obstructive inflammation. Flexible bronchoscopy revealed a nodular mass in the left main bronchus. Biopsy histopathology combined with immunohistochemistry confirmed the diagnosis of PMEC. Immunohistochemistry showed CK7 (+), P63 (-), P40 (-), CD117 (focal+), TTF-1 (-), NapsinA (-), and Ki-67 (7%+). Molecular testing identified a CRTC1-MAML2 gene fusion, whereas no classic driver gene mutations (e.g., EGFR or KRAS) were detected. PD-L1 expression was negative, and the tumor mutational burden (TMB) was low. The low Ki-67 index and positive MAML2 fusion in this case suggest a low-grade PMEC with a relatively favorable prognosis. The present study discusses the clinicopathological features, imaging findings, molecular diagnosis, and therapeutic advances of PMEC, along with a review of the relevant literature, aiming to increase clinical awareness of this rare disease.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China",
    "Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shaoyong Dong"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/64h5mvnj2evwt.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1893850",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696282/",
  "id": "64h5mvnj2evwt",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1893850",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2746|Salivary Gland Tumors Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221475896",
  "pdf_url": "https://europepmc.org/articles/PMC13696282?pdf=render",
  "pmcid": "PMC13696282",
  "pmid": "42935769",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/64h5mvnj2evwt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:40Z",
      "native_id": "PMC13696282",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1893850"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42935769",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935769"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Salivary Gland Tumors Diagnosis and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Primary pulmonary mucoepidermoid carcinoma: a case report",
  "title_text": "Primary pulmonary mucoepidermoid carcinoma: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:39Z",
  "url": "https://research.draconitic.com/paper/64h5mvnj2evwt",
  "venue": "Frontiers in Medicine",
  "versions": []
}