{
  "abstract": "Objectives: To estimate the incidence of reported retinal detachment (RD) after primary anti-vascular endothelial growth factor (anti-VEGF) treatment for retinopathy of prematurity (ROP) and to explore study-level factors associated with RD incidence. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched up to 24 May 2026, for English-language studies reporting RD outcomes after anti-VEGF monotherapy for ROP. Pooled incidence was estimated with a random-effects model using Freeman–Tukey double arcsine transformation. Heterogeneity, subgroup differences, publication bias, and leave-one-out sensitivity were assessed. Results: Twenty-seven studies (5598 eyes; 135 RD events) were included, comprising twelve case series, thirteen cohort studies, and two randomized controlled trials; thus, the evidence was predominantly retrospective. The pooled RD incidence was 1.4% (95% CI, 0.5–2.7%; I2 = 80.8%). The estimate remained stable on leave-one-out sensitivity analysis; the exclusion of Tong et al. markedly reduced heterogeneity. Higher RD incidence was observed in Asian studies, single-center studies, and studies with predominantly Zone I ROP or aggressive ROP (AROP). Incidence varied by postmenstrual age at treatment, gestational age, birth weight, and anti-VEGF agent. No significant publication bias was detected. Conclusions: RD after primary anti-VEGF therapy for ROP is uncommon but sight-threatening, with higher incidence associated with greater disease severity and postmenstrual age. Prolonged, risk-stratified follow-up is warranted for infants with Zone I or AROP. Standardized RD definitions, subtype classification, and severity-adjusted prospective comparisons are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, West China Second University Hospital, Sichuan University, Chengdu 610041, China",
    "Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China",
    "Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China",
    "Beijing Ophthalmology & Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China",
    "Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China",
    "Department of Ophthalmology, Xizang Hospital of West China Hospital, Sichuan University, Lhasa 857000, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Guina Liu",
      "orcid": "0000-0002-6733-4262"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Guojiao Song",
      "orcid": "0009-0003-1004-1973"
    },
    {
      "affs": [
        1
      ],
      "name": "Siqi Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Xu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Hanqing Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yunhan Tao"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Wenbin Wei",
      "orcid": "0000-0003-2386-0989"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Xiaoshuang Jiang",
      "orcid": "0000-0002-8401-6645"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hongtao Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/64yhy3wmeezbm.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15197598",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666268/?tool=EBI",
  "id": "64yhy3wmeezbm",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13666268",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Retinopathy of Prematurity Studies"
    ]
  ],
  "openalex": "W7214908844",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666268/pdf/?tool=EBI",
  "pmcid": "PMC13666268",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/64yhy3wmeezbm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "PMC:PMC13666268",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13666268"
    },
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15197598",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/19/7598"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Retinopathy of Prematurity Studies",
      "subfield": "imaging"
    }
  ],
  "title": "Reported Retinal Detachment in Anti-VEGF-Treated Retinopathy of Prematurity: A Systematic Review and Meta-Analysis",
  "title_text": "Reported Retinal Detachment in Anti-VEGF-Treated Retinopathy of Prematurity: A Systematic Review and Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:00Z",
  "url": "https://research.draconitic.com/paper/64yhy3wmeezbm",
  "venue": "Journal of clinical medicine",
  "versions": []
}