{
  "abstract": "Chikungunya fever, caused by the mosquito-borne chikungunya virus (CHIKV), poses a significant global health burden, with an estimated 16.9 million infections annually. Although CHIKV infection induces neutralizing antibody responses, data on their long-term persistence remain limited. In July 2017, an imported outbreak caused by the CHIKV East/Central/South African genotype occurred in Zhejiang Province, China. To assess the longevity of neutralizing antibodies, we conducted a cross-sectional follow-up study in August 2025, approximately eight years after infection. Two laboratory-confirmed patients from the outbreak were enrolled, and serum samples were collected. Serum neutralizing antibodies were measured using both pseudovirus and authentic CHIKV neutralization assays. Remarkably robust and sustained responses were observed in both patients. The pseudovirus neutralization titers were 225,677 and 134,460, respectively, and authentic virus neutralization titers were 9,133 and 4,951, respectively—which substantially exceeded the established protective threshold of 150. As no subsequent CHIKV outbreaks were documented in this non-endemic region, these high neutralizing antibody titers indicate that durable immunity may be derived from a single infection rather than repeated boosting. These findings suggest that natural CHIKV infection can elicit neutralizing antibodies that persist at high levels for at least eight years, providing evidence to inform the development of vaccines and vaccination strategies.",
  "abstract_shown": true,
  "affiliations": [
    "School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China",
    "State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China",
    "Bioinformatics Center of the Academy of Military Medical Science, Beijing 100850, China",
    "Department of Infectious Disease Control and Prevention, Quzhou Center for Disease Control and Prevention, Quzhou 324000, China"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xue-Li Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Meng-Fei Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Meng Kong"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi-Ming Ma"
    },
    {
      "affs": [
        2
      ],
      "name": "Xue-Jun Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Sheng Wan"
    },
    {
      "affs": [
        3
      ],
      "name": "Guo-Ping Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Rui-Rui Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi-Man Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Le-Le Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Xi"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Ping Yang"
    },
    {
      "affs": [
        3
      ],
      "name": "Bing-Dong Zhan"
    },
    {
      "affs": [
        0
      ],
      "name": "Mai-Juan Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/64zvdmda57rwe.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bsheal.2026.07.005",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729069/?tool=EBI",
  "id": "64zvdmda57rwe",
  "issns": [
    "2590-0536",
    "2096-6962"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729069",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Report"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7170058953",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729069/pdf/?tool=EBI",
  "pmcid": "PMC13729069",
  "pmid": "42979312",
  "published": "2026-07-22",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/64zvdmda57rwe.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13729069",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729069"
    },
    {
      "first_seen": "2026-11-07T12:21:54Z",
      "native_id": "PMC13729069",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bsheal.2026.07.005"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Persistent neutralizing antibodies against chikungunya virus eight years after infection",
  "title_text": "Persistent neutralizing antibodies against chikungunya virus eight years after infection",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:54Z",
  "url": "https://research.draconitic.com/paper/64zvdmda57rwe",
  "venue": "Biosafety and health",
  "versions": []
}