{
  "abstract": "Bone defects caused by aging and trauma present significant clinical challenges, driving intense research into bone regeneration strategies. Cellular behaviour during bone repair is critically regulated by the sustainable biophysical cues of the bone niche, particularly topography and electrical signals. Recent advances in biomaterial engineering now enable the precise modulation of these microenvironmental factors-through tuneable topographical and electroactive interfaces-to promote osteogenesis. This review examines emerging evidence on the individual and synergistic roles of surface topography and electrical stimulation in bone regeneration, highlighting their potential as non-pharmacological therapeutic approaches.",
  "abstract_shown": true,
  "affiliations": [
    "Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.",
    "Department of Orthopedic Dentistry, Faculty of Dentistry, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.",
    "School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.",
    "Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China. liwch57@mail.sysu.edu.cn.",
    "Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China. wangyan9@mail.sysu.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jingyan Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongheng Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yixuan Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Taras Vladimirovich Furtsev"
    },
    {
      "affs": [
        2
      ],
      "name": "Peng Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenye Hou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoshuang Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Weichang Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Yan Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6527c7hb0h3pj.bib",
  "cited_by": 0,
  "doi": "10.1186/s12951-026-04852-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13718004",
  "id": "6527c7hb0h3pj",
  "issns": [
    "1477-3155"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958509",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2204|Bone Tissue Engineering Materials"
    ]
  ],
  "openalex": "W7172116059",
  "pdf_url": "https://europepmc.org/articles/PMC13718004?pdf=render",
  "pmcid": "PMC13718004",
  "pmid": "42958509",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6527c7hb0h3pj.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958509",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958509"
    },
    {
      "first_seen": "2026-11-02T12:22:10Z",
      "native_id": "PMC13718004",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12951-026-04852-x"
    }
  ],
  "subjects": [],
  "title": "Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.",
  "title_text": "Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:10Z",
  "url": "https://research.draconitic.com/paper/6527c7hb0h3pj",
  "venue": "Journal of nanobiotechnology",
  "versions": []
}