{
  "abstract": "Metabolic dysfunction-associated steatotic liver disease (MASLD) is an important comorbidity in people living with HIV (PLWH), yet most data derive from individuals receiving antiretroviral therapy (ART). In the baseline cross-sectional analysis of the prospective multicentre MASHIV-TR cohort (nine centres, Türkiye), we compared 250 newly diagnosed, ART-naïve PLWH and 161 HIV-negative controls. Hepatic steatosis and liver stiffness were assessed by vibration-controlled transient elastography; MASLD was defined as hepatic steatosis, indicated by CAP ≥ 248 dB/m together with at least one cardiometabolic risk factor. MASLD prevalence was similar in the two groups (25.2% vs. 30.4%; p = 0.245), and HIV status was not independently associated with MASLD. Triglyceride level was independently associated with CAP in PLWH (+10.69 dB/m per 50 mg/dL) and in controls (+9.26 dB/m), whereas CD4 and CD8 counts, the CD4/CD8 ratio and HIV-RNA were not associated with the liver outcomes. Before ART, hepatic steatosis tracked metabolic rather than HIV-specific markers.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dicle University, Diyarbakır 21280, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Çukurova University, Adana 01330, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep 27310, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, İzmir 35100, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya 07070, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Prof. Dr. Cemil Taşçıoğlu City Hospital, University of Health Sciences Türkiye, İstanbul 34384, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Harran University, Şanlıurfa 63300, Türkiye.",
    "Department of Internal Medicine, Division of General Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.",
    "Epidemiology Doctorate Program, Graduate School of Health Sciences, Istanbul Medipol University, İstanbul 34815, Türkiye.",
    "Department of Biostatistics and Medical Informatics, Faculty of Medicine, Dicle University, Diyarbakır 21280, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Acıbadem Adana Hospital, Adana 01130, Türkiye.",
    "Department of Infectious Diseases and Clinical Microbiology, Güven Hospital, Ankara 06540, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Çiğdem Mermutluoğlu",
      "orcid": "0000-0003-1836-6281"
    },
    {
      "affs": [
        1
      ],
      "name": "Yeşim Taşova"
    },
    {
      "affs": [
        2
      ],
      "name": "Ayşe Özlem Mete"
    },
    {
      "affs": [
        2
      ],
      "name": "İlkay Karaoğlan"
    },
    {
      "affs": [
        3
      ],
      "name": "Hüsnü Pullukçu"
    },
    {
      "affs": [
        4
      ],
      "name": "Meliha Çağla Sönmezer"
    },
    {
      "affs": [
        5
      ],
      "name": "Dilara İnan"
    },
    {
      "affs": [
        6
      ],
      "name": "Funda Şimşek"
    },
    {
      "affs": [
        7
      ],
      "name": "Sıla Akhan"
    },
    {
      "affs": [
        8
      ],
      "name": "Tuba Damar Çakırca"
    },
    {
      "affs": [
        9
      ],
      "name": "Nursel Çalık Başaran"
    },
    {
      "affs": [
        1
      ],
      "name": "Aslıhan Candevir",
      "orcid": "0000-0001-9340-516X"
    },
    {
      "affs": [
        10
      ],
      "name": "Yeliz Çiçek",
      "orcid": "0000-0002-4061-2322"
    },
    {
      "affs": [
        1
      ],
      "name": "Damla Ertürk",
      "orcid": "0000-0002-2163-5844"
    },
    {
      "affs": [
        4
      ],
      "name": "Ahmet Çağkan İnkaya",
      "orcid": "0000-0001-7943-8715"
    },
    {
      "affs": [
        11
      ],
      "name": "İsmail Yıldız",
      "orcid": "0000-0001-5505-838X"
    },
    {
      "affs": [
        12
      ],
      "name": "Behice Kurtaran"
    },
    {
      "affs": [
        7
      ],
      "name": "Müge Toygar Deniz",
      "orcid": "0000-0002-6946-2727"
    },
    {
      "affs": [
        13
      ],
      "name": "Yaşar Bayındır"
    },
    {
      "affs": [
        0
      ],
      "name": "Mustafa Kemal Çelen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/65kz2827dr5q0.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198672",
  "fulltext_url": "https://europepmc.org/articles/PMC13664788",
  "id": "65kz2827dr5q0",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883917",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214575874",
  "pdf_url": "https://europepmc.org/articles/PMC13664788?pdf=render",
  "pmcid": "PMC13664788",
  "pmid": "42883917",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/65kz2827dr5q0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883917",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883917"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Baseline Liver Metabolic Health in Newly Diagnosed People Living with HIV Compared with HIV-Negative Controls: Cross-Sectional Findings from the Prospective MASHIV-TR Cohort.",
  "title_text": "Baseline Liver Metabolic Health in Newly Diagnosed People Living with HIV Compared with HIV-Negative Controls: Cross-Sectional Findings from the Prospective MASHIV-TR Cohort.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/65kz2827dr5q0",
  "venue": "International journal of molecular sciences",
  "versions": []
}