{
  "abstract": "NSAIDs pose a significant risk to the stomach and kidneys, with oxidative stress being a key driver in the development of indomethacin-induced gastric ulcers and acute kidney injury by disrupting the balance between oxidation and antioxidation. Effective management of oxidative stress and bolstering antioxidant defenses are crucial strategies for preventing and treating these conditions. This study explored the potential of Aerva javanica, a plant abundant in Saudi Arabia and used in traditional medicine, to mitigate these adverse effects. Researchers identified 27 phytochemicals in its leaf extract using LC-MS and synthesized silver nanoparticles (SNPs), characterizing them with TEM and UV-visible spectrophotometry. Network analysis suggested a link between procyanidin dimer and kaempferol 4’-O-methyl ether with genes protecting the kidneys and stomach, possibly involving the AGE-RAGE and HIF-1 signaling pathways. In vivo experiments using an indomethacin-induced injury model demonstrated that administering A. javanica resulted in a dose-dependent decrease in gastric ulcer severity and a return of elevated serum renal markers to normal levels. Furthermore, the treatment reduced oxidative stress markers (MDA) and increased antioxidant levels (GSH) in both the stomach and kidneys. A. javanica also suppressed the expression of pro-inflammatory markers and inhibited the NF-κB p65 and STAT-3 signaling pathways. Histological examination corroborated these protective effects. The observed scavenging activity of A. javanica is attributed to its rich content of flavonoids and phenolic compounds. These findings suggest that A. javanica offers promising gastroprotective and nephroprotective properties against NSAID-induced complications by reducing oxidative stress and inflammation through the coordinated regulation of key signaling pathways.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacognosy, College of Pharmacy, Najran University, Najran, Saudi Arabia",
    "Health Research Center, Najran University, Najran, Saudi Arabia",
    "Department of Biochemistry & Molecular Biology, Faculty of Pharmacy, Deraya University, Minia, Egypt",
    "Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia",
    "Department of Pharmacognosy, College of Pharmacy, King Khalid, Abha, Saudi Arabia",
    "Department of Pharmacognosy and Phytochemistry, College of Pharmacy, The Islamic University, Najaf, Iraq",
    "Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo, Egypt",
    "Department of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida university, Sharkia, Egypt",
    "Department of Pathology, Deraya University, Universities Zone, New Minia City, Egypt",
    "Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt",
    "Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia, Egypt"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hany G. Attia"
    },
    {
      "affs": [
        1
      ],
      "name": "Dalia H. Abu-Baih"
    },
    {
      "affs": [
        2
      ],
      "name": "Bassam S. M. Al kazman"
    },
    {
      "affs": [
        3
      ],
      "name": "A. Maqboul"
    },
    {
      "affs": [
        4
      ],
      "name": "Mohamed A. Rabeh"
    },
    {
      "affs": [
        5
      ],
      "name": "Saad Ali Alshehri"
    },
    {
      "affs": [
        6
      ],
      "name": "Ali Al-shabi"
    },
    {
      "affs": [
        7
      ],
      "name": "Mohamed A. Zarka"
    },
    {
      "affs": [
        8
      ],
      "name": "Sameh S. Zaghlool"
    },
    {
      "affs": [
        9
      ],
      "name": "Fatma Alzahraa Mokhtar"
    },
    {
      "affs": [
        10
      ],
      "name": "Nehad M. Reda Abdel-maqsoud"
    },
    {
      "name": "Usama Ramadan Abdelmohsen"
    },
    {
      "name": "Khayrya A. Youssif"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/65s4nd5ek816x.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0358843",
  "fulltext_url": null,
  "id": "65s4nd5ek816x",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0358843",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Anatomy/Digestive system/Gastrointestinal tract/Stomach"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Renal system/Kidneys"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/DNA-binding proteins/Transcription factors"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Regulatory proteins/Transcription factors"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Oxidative stress"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Gene expression/Gene regulation/Transcription factors"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Immune response/Inflammation"
    ],
    [
      "plos",
      "/Engineering and technology/Nanotechnology/Nanoparticles"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Digestive system/Gastrointestinal tract/Stomach"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Renal system/Kidneys"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Edema"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Inflammation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Ulcers"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune response/Inflammation"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/65s4nd5ek816x.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:42Z",
      "native_id": "10.1371/journal.pone.0358843",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0358843"
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
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    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Nephroprotective and Gastroprotective potential of Aerva javanica (L.) green synthesized nanoparticles, supported by Molecular Networking",
  "title_text": "Nephroprotective and Gastroprotective potential of Aerva javanica (L.) green synthesized nanoparticles, supported by Molecular Networking",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:24Z",
  "url": "https://research.draconitic.com/paper/65s4nd5ek816x",
  "venue": "PLOS One",
  "versions": []
}