{
  "abstract": "Background: In locally advanced esophagogastric adenocarcinoma (EGA), perioperative chemotherapy is the standard of care and can result in complete/major pathological response. In this setting, real-world data on the impact of postoperative chemotherapy are scarce. Objective: The primary objective was to assess the impact of postoperative chemotherapy on overall survival (OS) in cases of complete/major pathological response and/or no serosal involvement. Secondary endpoints were disease-free survival (DFS) and the identification of predictive factors associated with OS. Design: A retrospective comparative multicentric study was conducted using the nationwide, prospectively collected FREGAT (FRench EsoGAstric Tumor) database. Methods: Patients with EGA treated with perioperative chemotherapy registered in the FREGAT database who had a complete/major pathological response and/or no serosal involvement (ypT0–2 or ypT3 Mandard TRG 2, ypN0, R0) were included. Results: Among 1870 patients with EGA treated with perioperative chemotherapy identified in the FREGAT database, 345 met the inclusion criteria, and 218 (63.2%) received postoperative chemotherapy. Postoperative chemotherapy was associated with OS improvement regardless of the regimen used (median OS: not achieved vs 65.7 months; p < 0.0001). Similarly, DFS was improved with postoperative chemotherapy (median DFS: not achieved vs 65.7 months; p < 0.0001). In multivariable analysis, age, primary tumor location, postoperative complications, and no postoperative chemotherapy were associated with poorer survival outcomes. Conclusion: Postoperative chemotherapy after resection of EGA with complete/major pathological response and/or tumors without serosal involvement remains the standard of care, improves survival outcomes, and should be recommended when the patient’s condition allows it.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 29,
  "authors": [
    {
      "name": "Laure Corazzin"
    },
    {
      "name": "Elodie Jeanbert"
    },
    {
      "name": "Olivier Glehen"
    },
    {
      "name": "Caroline Gronnier"
    },
    {
      "name": "Laurent Sulpice"
    },
    {
      "name": "Jean-Marc Gornet"
    },
    {
      "name": "Brice Paquette"
    },
    {
      "name": "Jean-Marc Regimbeau"
    },
    {
      "name": "Cécile Brigand"
    },
    {
      "name": "Xavier-Benoît D’journo"
    },
    {
      "name": "Pierre-Yves Brichon"
    },
    {
      "name": "Johan Gagnaire"
    },
    {
      "name": "Thibault Voron"
    },
    {
      "name": "Muriel Mathonnet"
    },
    {
      "name": "Christophe Penna"
    },
    {
      "name": "Nicolas Regenet"
    },
    {
      "name": "Côme Lepage"
    },
    {
      "name": "Nicolas Carrere"
    },
    {
      "name": "Ugo Marchese"
    },
    {
      "name": "Leonor Benhaim"
    },
    {
      "name": "Jean-Michel Fabre"
    },
    {
      "name": "Frédéric Di Fiore"
    },
    {
      "name": "Frédéric Borie"
    },
    {
      "name": "Pierre Emmanuel Bonnot"
    },
    {
      "name": "Olivier Bouché"
    },
    {
      "name": "David Tougeron"
    },
    {
      "name": "Antoine Adenis"
    },
    {
      "name": "Guillaume Piessen"
    },
    {
      "name": "Marie Muller"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/65ytdq9dgh08h.bib",
  "cited_by": 0,
  "doi": "10.1177/17588359261435406",
  "fulltext_url": null,
  "id": "65ytdq9dgh08h",
  "issns": [
    "1758-8340",
    "1758-8359"
  ],
  "landing_url": "https://u-picardie.hal.science/hal-05712630v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.chi"
    ],
    [
      "hal",
      "2.sdv.mhep.heg"
    ],
    [
      "openalex",
      "2740|Gastric Cancer Management and Outcomes"
    ]
  ],
  "openalex": "W7168380064",
  "pdf_url": "https://u-picardie.hal.science/hal-05712630/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-15",
  "publisher": "SAGE Journals",
  "ris": "https://research.draconitic.com/paper/65ytdq9dgh08h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "hal-05712630",
      "source": "hal",
      "url": "https://u-picardie.hal.science/hal-05712630v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.chi",
      "subfield": "surgery"
    }
  ],
  "title": "Impact of postoperative chemotherapy in patients resected for esophagogastric adenocarcinoma with major pathological response after preoperative chemotherapy: a study from the FREGAT database",
  "title_text": "Impact of postoperative chemotherapy in patients resected for esophagogastric adenocarcinoma with major pathological response after preoperative chemotherapy: a study from the FREGAT database",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/65ytdq9dgh08h",
  "venue": "Therapeutic Advances in Medical Oncology",
  "versions": []
}