{
  "abstract": "Sulfur hexafluoride (SF6) is a potent greenhouse gas whose direct use as a fluorine source in organic synthesis remains underdeveloped. Here, we disclose complementary photoredox and electrochemical strategies for nucleophilic fluorinations with SF6, merging oxidative formation of carbocation intermediated from alkoxamines, carboxylic acids, or thiols with SF6 reduction, the latter providing fluoride for C(sp3)–F bond formation. The photochemical protocol efficiently converts electronrich substrates and tolerates a broad range of functional groups, whereas paired electrolysis extends the reaction to electronically deactivated substrates. Together, the two methods enable fluorination of diverse benzylic and aliphatic substrates, including late-stage fluorination of structurally complex derivatives of pharmaceuticals, natural products, and agrochemicals.",
  "abstract_shown": true,
  "affiliations": [
    "Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Helmholtz Center for Infection Research (HZI",
    "Organic Chemistry – Biomimetic Catalysis",
    "Saarland University",
    "Pharma Science Hub"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Aniruddha Biswas",
      "orcid": "0000-0002-4757-3258"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Demetra Zambardino",
      "orcid": "0009-0007-7645-1157"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Tanja Gulder",
      "orcid": "0000-0003-4870-2266"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/65z02yxcz8rwa.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009734/v1",
  "fulltext_url": null,
  "id": "65z02yxcz8rwa",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009734/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7215100018",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009734/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/65z02yxcz8rwa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009734",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009734/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Redox-Paired Activation of Sulfur Hexafluoride Enables Nucleophilic C(sp3)–F Bond Formation",
  "title_text": "Redox-Paired Activation of Sulfur Hexafluoride Enables Nucleophilic C(sp3)–F Bond Formation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/65z02yxcz8rwa",
  "venue": "ChemRxiv",
  "versions": []
}