{
  "abstract": "Central nervous system (CNS) neoplasms are uncommon but highly consequential malignancies that account for substantial neurological disability and premature mortality. The Middle East and North Africa (MENA) region is marked by rapid population growth, aging, and uneven health system capacity, yet comprehensive long-term evaluations of CNS neoplasm burden across countries, sexes, and age groups remain limited. We analyzed data from the Global Burden of Disease 2023 study to assess trends in incidence, prevalence, and mortality from CNS neoplasms in the MENA region from 1990 to 2023, with projections to 2050. Age-standardized incidence, prevalence, and mortality rates per 1,00,000 population were estimated. Temporal trends were evaluated using Joinpoint regression to calculate annual percent change and average annual percent change (AAPC) with 95% confidence intervals. Analyses were stratified by sex, age group, and country. Between 1990 and 2023, the age-standardized mortality rate remained largely stable with a small but significant upward trend (AAPC 0.09%). Mortality rates were consistently higher among males. Adults aged 20 years and older experienced rising age-standardized mortality (AAPC 0.58%), whereas mortality declined among individuals younger than 20 years (AAPC-0.90%). Incidence increased in both absolute numbers and age-standardized rates (AAPC 0.42%). Prevalence also rose steadily, with the age-standardized prevalence rate increasing from 13.46 to 19.51 per 1,00,000 (AAPC 1.13%), driven mainly by adults. The burden of CNS neoplasms in the MENA region has intensified over the past 3 decades, highlighting the need for improved surveillance, earlier diagnosis, and expanded access to specialized neuro-oncological care.",
  "abstract_shown": true,
  "affiliations": [
    "Dermatology Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.",
    "Department of Medical Surgical Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.",
    "King Faisal University, Al-Ahsa, Saudi Arabia.",
    "College of Medicine, Shaqra campus, Shaqra University, Shaqra, Saudi Arabia.",
    "College of Medicine, Jeddah University, Jeddah, Saudi Arabia.",
    "King Khalid University, Abha, Saudi Arabia.",
    "College of Medicine, Qassim University, Qassim, Saudi Arabia.",
    "College of Medicine, King Faisal University, Hofuf, Saudi Arabia.",
    "Ibn Sina National College, Jeddah, Saudi Arabia.",
    "Batterjee Medical College (BMC), Asir, Saudi Arabia.",
    "Faculty of Medicine, Lebanese University, Beirut, Lebanon.",
    "Armed Forces Hospital Southern Region, Ministry of Defense Health Services, Khamis Mushait, Saudi Arabia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ibraheem Altamimi"
    },
    {
      "affs": [
        1
      ],
      "name": "Alaa Alanazi"
    },
    {
      "affs": [
        2
      ],
      "name": "Abdullah Abdulaziz Alnaim"
    },
    {
      "affs": [
        3
      ],
      "name": "Ahmed Khalid Alzahrani"
    },
    {
      "affs": [
        4
      ],
      "name": "Yousef Saeed Alzahrani"
    },
    {
      "affs": [
        5
      ],
      "name": "Abdulelah Mohammed Abdullah Alsakti"
    },
    {
      "affs": [
        6
      ],
      "name": "Norah Abdullah Alodhaib"
    },
    {
      "affs": [
        7
      ],
      "name": "Ali Abdulhakim Alhakeem"
    },
    {
      "affs": [
        8
      ],
      "name": "Mohammed Mastour Alharthi"
    },
    {
      "affs": [
        9
      ],
      "name": "Raghad Emad Alhalabi"
    },
    {
      "affs": [
        10
      ],
      "name": "Aalaa Saleh",
      "orcid": "0000-0002-9046-3003"
    },
    {
      "affs": [
        11
      ],
      "name": "Jaber Abdullah Alshahrani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/65z5h0smx17eq.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051128",
  "fulltext_url": "https://europepmc.org/articles/PMC13681167",
  "id": "65z5h0smx17eq",
  "issns": [
    "0304-5412",
    "1536-5964"
  ],
  "landing_url": "https://europepmc.org/article/MED/42888625",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Global Cancer Incidence and Screening"
    ]
  ],
  "openalex": "W7222400456",
  "pdf_url": "https://europepmc.org/articles/PMC13681167?pdf=render",
  "pmcid": "PMC13681167",
  "pmid": "42888625",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/65z5h0smx17eq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42888625",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888625"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Global Cancer Incidence and Screening",
      "subfield": "oncology"
    }
  ],
  "title": "Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050: Insights from Global Burden of Disease.",
  "title_text": "Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050: Insights from Global Burden of Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/65z5h0smx17eq",
  "venue": "Medicine",
  "versions": []
}