{
  "abstract": "Background: Although outcomes after transcatheter aortic valve replacement (TAVR) have improved, heart failure (HF) hospitalization, ischemic events, and major bleeding remain clinical challenges in patients with severe aortic stenosis.\n\nObjectives: The objective of the study was to evaluate the incidence, timing, and prognostic impact of these events after TAVR.\n\nMethods: This two-center retrospective registry included 988 patients with severe aortic stenosis who underwent TAVR. Patients were grouped according to the first clinical event after discharge: HF hospitalization, ischemic events (myocardial infarction or ischemic stroke), major bleeding, or the event-free group. The timing of the first postdischarge event and all-cause mortality after the first event were evaluated.\n\nResults: During a median follow-up of 665 days after discharge, 165 patients (16.7%) experienced any of these events. As first events, HF hospitalization, ischemic events, and major bleeding occurred in 80 (8.1%), 32 (3.2%), and 53 (5.4%) patients, respectively, whereas 823 (83.3%) were in the event-free group. Among patients with a first postdischarge event, major bleeding occurred earliest among the 3 event groups. One-year all-cause mortality after the first event was high across groups (HF hospitalization, 31.5%; ischemic events, 30.4%; major bleeding, 25.4%).\n\nConclusions: Among patients who experienced a first postdischarge event after TAVR, major bleeding occurred earlier than HF hospitalization or ischemic events. Once a first postdischarge event occurred, subsequent all-cause mortality was high across the 3 event groups. These findings suggest that event timing should be considered and careful clinical reassessment may be warranted when a first postdischarge event occurs after TAVR.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiovascular Medicine, Chiba University Hospital, Chiba, Japan",
    "Department of Cardiology, Chiba Cerebral and Cardiovascular Center, Chiba, Japan",
    "Department of Cardiovascular Surgery, Chiba University Hospital, Chiba, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shogo Okita"
    },
    {
      "affs": [
        0
      ],
      "name": "Hideki Kitahara"
    },
    {
      "affs": [
        1
      ],
      "name": "Hiroki Kuji"
    },
    {
      "affs": [
        0
      ],
      "name": "Ko Miyakoda"
    },
    {
      "affs": [
        2
      ],
      "name": "Ryo Toishi"
    },
    {
      "affs": [
        2
      ],
      "name": "Tomoyoshi Kanda"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuichi Saito"
    },
    {
      "affs": [
        1
      ],
      "name": "Kousei Tanaga"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoshitake Nakamura"
    },
    {
      "affs": [
        2
      ],
      "name": "Kaoru Matsuura"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshio Kobayashi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/66ajwq15ne1cy.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacadv.2026.103387",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734917/",
  "id": "66ajwq15ne1cy",
  "issns": [
    "2772-963X"
  ],
  "landing_url": "https://doi.org/10.1016/j.jacadv.2026.103387",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7223670566",
  "pdf_url": null,
  "pmcid": "PMC13734917",
  "pmid": "42933361",
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/66ajwq15ne1cy.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:43Z",
      "native_id": "PMC13734917",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jacadv.2026.103387"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Patterns of Postdischarge Heart Failure, Ischemic, and Bleeding Events After Transcatheter Aortic Valve Replacement",
  "title_text": "Patterns of Postdischarge Heart Failure, Ischemic, and Bleeding Events After Transcatheter Aortic Valve Replacement",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:43Z",
  "url": "https://research.draconitic.com/paper/66ajwq15ne1cy",
  "venue": "JACC: Advances",
  "versions": []
}