{
  "abstract": "Skeletal muscle aging is a conserved biological process characterized by progressive declines in muscle mass, strength, regenerative capacity, and metabolic adaptability, contributing to impaired mobility, frailty and age-related diseases. Beyond its canonical role in locomotion, skeletal muscle functions as an endocrine and metabolic organ that actively regulates organismal aging through myokines, metabolites, extracellular vesicles, thermogenic activity, and dynamic communication with distant organs. In this review, we summarize the intrinsic mechanisms driving skeletal muscle aging, including protein turnover imbalance and anabolic resistance, myosteatosis, denervation and motor unit loss, and cellular composition remodeling. We also discuss how aging skeletal muscle influences systemic aging through bidirectional interactions with metabolic organs, brain, cardiovascular system, and bone via endocrine signaling and interorgan communication. Finally, we highlight emerging interventions targeting skeletal muscle aging, including exercise, nutritional strategies, pharmacological approaches, and other novel therapies. Understanding skeletal muscle as both a target and regulator of systemic aging provides a framework for developing strategies to promote healthy aging and reduce the burden of age-associated diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China",
    "Diabetes and Metabolic Disease Clinical Research Center of Hubei Province, Wuhan 430022, China",
    "Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan 430022, China",
    "Hubei Branch of National Center for Clinical Medical Research of Metabolic Diseases, Wuhan 430022, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Mei-Mei Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Xinwei Liu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yixuan Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Han Li"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Yuhao Wang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Kangli Qiu"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Wen Kong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/66b5k2a391bmz.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101527",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702484/?tool=EBI",
  "id": "66b5k2a391bmz",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1527",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7223027541",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702484/pdf/?tool=EBI",
  "pmcid": "PMC13702484",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/66b5k2a391bmz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101527",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1527"
    },
    {
      "first_seen": "2026-10-30T12:21:44Z",
      "native_id": "PMC:PMC13702484",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702484"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Skeletal Muscle Aging Is a Significant Contributor to Systemic Aging",
  "title_text": "Skeletal Muscle Aging Is a Significant Contributor to Systemic Aging",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:44Z",
  "url": "https://research.draconitic.com/paper/66b5k2a391bmz",
  "venue": "Biomolecules",
  "versions": []
}