{
  "abstract": "Purpose\n\nActivation of epidermal growth factor receptor (EGFR) signaling in airway epithelial cells leads to epithelial-mesenchymal transformation (EMT) and airway remodeling in asthma. However, the mechanism regulating EGFR expression is not fully understood. We hypothesized that cadherin-26 (CDH26), a highly expressed cadherin in airway epithelium, promotes airway remodeling via regulating EGFR signaling in asthma.Methods\n\nThe expression of CDH26 in airway brush cells of asthmatic patients was examined using quantitative polymerase chain reaction. Airway hyperresponsiveness and remodeling were assessed in the house dust mite (HDM)-sensitized and -challenged Cdh26-deficient mice. The role and mechanism of CDH26 in epidermal growth factor (EGF)-induced EMT were measured in cultured human bronchial epithelial BEAS-2B cells.Results\n\nThe expression of CDH26 in airway brush cells was significantly correlated with the thickness of airway basement membrane in asthma patients. Cdh26 deficiency significantly reduced airway hyperresponsiveness and remodeling in HDM-sensitized and -challenged mouse model. In cultured human bronchial epithelial BEAS-2B cells, CDH26 knockdown inhibited EGF-induced EMT, whereas overexpression of CDH26 promoted EGF-induced EMT. Furthermore, CDH26 knockdown suppressed EGF-induced activation of EGFR signaling including phosphatidylinositol 3-kinase and AKT phosphorylation. By contrast, CDH26 overexpression intensified EGF-induced activation of EGFR signaling. Mechanistically, CDH26 knockdown promoted the proteasomal degradation of the EGFR.Conclusions\n\nCDH26 promoted airway remodeling via stabilizing the epithelial expression of EGFR and sustaining the activation of EGFR signaling in asthma. Thus, CDH26 can be a potential therapeutic target for airway remodeling in asthma.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
    "Key Laboratory of Respiratory Diseases, National Health Commission of the People's Republic of China, and National Clinical Research Center for Respiratory Diseases, Wuhan, China.",
    "Department of Respiratory and Critical Care Medicine, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.",
    "Department of General Practice, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
    "Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China. chengdan729@126.com.",
    "Key Laboratory of Respiratory Diseases, National Health Commission of the People's Republic of China, and National Clinical Research Center for Respiratory Diseases, Wuhan, China. ghzhen@tjh.tjmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jiali Gao"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Gongqi Chen",
      "orcid": "0009-0009-4860-1335"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chunli Huang",
      "orcid": "0009-0003-0905-7943"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhen Wang",
      "orcid": "0000-0002-9151-7958"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Gu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Huiru Jie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tiantian Xiong",
      "orcid": "0009-0007-6954-4857"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuchen Feng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lingling Yi"
    },
    {
      "affs": [
        4
      ],
      "name": "Dan Cheng",
      "orcid": "0000-0002-5488-1937"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Guohua Zhen",
      "orcid": "0000-0001-5582-7900"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/66q5fnp4cnb15.bib",
  "cited_by": 0,
  "doi": "10.4168/aair.2026.18.5.702",
  "fulltext_url": "https://europepmc.org/articles/PMC13655397",
  "id": "66q5fnp4cnb15",
  "issns": [
    "2092-7355",
    "2092-7363"
  ],
  "landing_url": "https://europepmc.org/article/MED/42845226",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7214734705",
  "pdf_url": "https://europepmc.org/articles/PMC13655397?pdf=render",
  "pmcid": "PMC13655397",
  "pmid": "42845226",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/66q5fnp4cnb15.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42845226",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42845226"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Cadherin-26 Promotes Airway Remodeling via Stabilizing Epithelial Expression of the Epidermal Growth Factor Receptor in Asthma.",
  "title_text": "Cadherin-26 Promotes Airway Remodeling via Stabilizing Epithelial Expression of the Epidermal Growth Factor Receptor in Asthma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/66q5fnp4cnb15",
  "venue": "Allergy, asthma & immunology research",
  "versions": []
}