{
  "abstract": "Cardiac troponin is essential for diagnosing myocardial infarction, yet high-sensitivity assays frequently detect troponin elevations in non-ischemic contexts, complicating clinical decision-making. We investigated extracellular vesicle-associated (EV) versus non-vesicular (NEV) troponin in plasma samples from 266 participants across acute and chronic heart failure, type 1 and type 2 MI, hypertrophic cardiomyopathy, end-stage kidney disease, healthy individuals, and exercise states. EV troponin was negligible in necrosis-dominant conditions (MI, kidney disease) but constituted up to 40-60% of total troponin in chronic heart failure or hypertrophic cardiomyopathy; in healthy controls and athletes, troponin concentrations were near or below the detection limit, though detectable troponin was predominantly EV-associated. Unlike plasma troponin, EV troponin weakly correlated with natriuretic peptides or renal indices, suggesting a distinct release mechanism linked to chronic stress or physiological processes. These findings highlight the potential for EV troponin to distinguish active, non-necrotic processes from acute injury. Further study may clarify its prognostic utility and refine current diagnostics and risk stratification.",
  "abstract_shown": true,
  "affiliations": [
    "Albert Einstein College of Medicine, New York City Health and Hospitals, North Central Bronx, The Bronx, NY, USA",
    "Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Mass General Brigham Heart and Vascular Institute, 185 Cambridge Street, Simches 3, Boston, MA, 02114, USA",
    "Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA",
    "Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA",
    "Baim Institute for Clinical Research, Boston, MA, USA",
    "Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Mass General Brigham Heart and Vascular Institute, 185 Cambridge Street, Simches 3, Boston, MA, 02114, USA. sdas@mgh.harvard.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Michail Spanos",
      "orcid": "0000-0003-1205-4201"
    },
    {
      "affs": [
        1
      ],
      "name": "Priyanka Gokulnath",
      "orcid": "0000-0003-2813-330X"
    },
    {
      "affs": [
        1
      ],
      "name": "Aarush Singh",
      "orcid": "0009-0002-0419-3973"
    },
    {
      "affs": [
        1
      ],
      "name": "Christopher Azzam",
      "orcid": "0009-0007-1500-8127"
    },
    {
      "affs": [
        1
      ],
      "name": "Ronak Wakhlu"
    },
    {
      "affs": [
        2
      ],
      "name": "Claire Lin",
      "orcid": "0009-0006-7201-7567"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana-Chrysa Maravelias"
    },
    {
      "affs": [
        3
      ],
      "name": "Timothy Oasan"
    },
    {
      "affs": [
        2
      ],
      "name": "Albree F Tower-Rader",
      "orcid": "0000-0001-7242-0774"
    },
    {
      "affs": [
        2
      ],
      "name": "Megan Wasfy"
    },
    {
      "affs": [
        3
      ],
      "name": "Petr Jarolı́m",
      "orcid": "0000-0002-9612-8652"
    },
    {
      "affs": [
        4,
        2
      ],
      "name": "James L. Januzzi",
      "orcid": "0000-0002-8338-1798"
    },
    {
      "affs": [
        5
      ],
      "name": "Saumya Das",
      "orcid": "0000-0002-4521-4606"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/66ybvperjqxrg.bib",
  "cited_by": 6,
  "doi": "10.1186/s40364-026-00947-7",
  "fulltext_url": null,
  "id": "66ybvperjqxrg",
  "issns": [
    "2050-7771"
  ],
  "landing_url": "https://doi.org/10.1186/s40364-026-00947-7",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7162802190",
  "pdf_url": null,
  "pmcid": "PMC13330230",
  "pmid": "42216022",
  "published": "2026-05-29",
  "publisher": "BioMed Central",
  "ris": "https://research.draconitic.com/paper/66ybvperjqxrg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:48Z",
      "native_id": "W7162802190",
      "source": "openalex",
      "url": "https://doi.org/10.1186/s40364-026-00947-7"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The actively secreted plasma extracellular vesicle troponin (ASPECT) study: circulating troponin in extracellular vesicles across cardiovascular disease cohorts",
  "title_text": "The actively secreted plasma extracellular vesicle troponin (ASPECT) study: circulating troponin in extracellular vesicles across cardiovascular disease cohorts",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T13:20:13Z",
  "url": "https://research.draconitic.com/paper/66ybvperjqxrg",
  "venue": "Biomarker Research",
  "versions": []
}