{
  "abstract": "Cutaneous sebaceous neoplasms are rare adnexal tumours differentiated towards sebaceous glands, spanning a biological spectrum from benign (sebaceous adenoma, sebaceoma, nevus sebaceus) to outright malignant (sebaceous carcinoma). Most tumours are sporadic and solitary, with a predilection for the head and neck of elderly adults, but a clinically important subset is observed in the setting of Lynch syndrome/Muir-Torre syndrome. Recent large-scale genomic and transcriptomic studies have provided insights into the pathogenesis of these unique neoplasms, revealing a genetically heterogeneous landscape shaped by mismatch repair deficiency, UV damage, and abnormalities in several other key signalling pathways. The inclusion of nevus sebaceus within the sebaceous tumour family in the WHO 5th Edition of Skin Tumours reflects a conceptual shift, recognising nevus sebaceus as a clonal, mutation-driven neoplasm and a precursor lesion for secondary tumour development.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.",
    "Department of Pathology, Clinique Universitaire Saint-Luc, Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.",
    "Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.",
    "Somatic Functional Genomics and Cancer, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Katharina Wiedemeyer"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Ingrid Ferreira",
      "orcid": "0000-0002-4321-5250"
    },
    {
      "affs": [
        3
      ],
      "name": "David J Adams",
      "orcid": "0000-0001-9490-0306"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Brenn"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/670sw0c60wqt5.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18193209",
  "fulltext_url": "https://europepmc.org/articles/PMC13664556",
  "id": "670sw0c60wqt5",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882904",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Cancer and Skin Lesions"
    ]
  ],
  "openalex": "W7220448869",
  "pdf_url": "https://europepmc.org/articles/PMC13664556?pdf=render",
  "pmcid": "PMC13664556",
  "pmid": "42882904",
  "published": "2026-10-04",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/670sw0c60wqt5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42882904",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882904"
    },
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18193209",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/19/3209"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6694",
      "subfield": "oncology"
    }
  ],
  "title": "Cutaneous Neoplasms with Sebaceous Differentiation: A Comprehensive Update on Clinical, Histopathological and Molecular Classification.",
  "title_text": "Cutaneous Neoplasms with Sebaceous Differentiation: A Comprehensive Update on Clinical, Histopathological and Molecular Classification.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:58Z",
  "url": "https://research.draconitic.com/paper/670sw0c60wqt5",
  "venue": "Cancers",
  "versions": []
}