{
  "abstract": "BACKGROUND: Hypertension is a significant public health issue affecting over a billion adults worldwide with adherence to antihypertensives being crucial for achieving sustained blood pressure control and reducing cardiovascular morbidity and mortality. To extend previous evidence, we conducted a meta-analysis on global prevalence of adherence to antihypertensives among adults. METHODS: statistics examined statistical heterogeneity with moderator analysis exploring sources of heterogeneity. Sensitivity analysis was analyzed using exact fixed-effects model. RESULTS: A total of 123 studies with 1 052 445 adults with hypertension were included. Pooled global prevalence of adherence to antihypertensives was estimated at 58% (95% CI, 52%-63%), with 39% for high adherence, 29% for moderate adherence, and 35% for low adherence. Results for sensitivity analysis were 57.91% (95% CI, 57.81%-58.01%) with δ̂ being 24.3%. Prevalence across continents was 67% for Europe, 65% for South America, 60% for Africa, 56% for Asia, and 45% for North America. Adherence to antihypertensives was similar across low-income countries (61%), high-income countries (58), upper-middle-income countries (57%), and lower-middle-income countries (56%). In multivariate model, age and assessment tool only were significantly associated with medication adherence. CONCLUSIONS: Globally, a large proportion of adults with hypertension exhibit moderate to low adherence to antihypertensive medications. Future studies should prioritize establishing consensus-based operational definitions and cutoff values to enhance adherence.",
  "abstract_shown": true,
  "affiliations": [
    "National Taipei University of Nursing and Health Sciences",
    "Mzimba District Hospital",
    "St John's Institute for Health",
    "Taipei Medical University",
    "Kamuzu University of Health Sciences",
    "University of Wisconsin–Milwaukee",
    "Mzuzu Central Hospital",
    "Independent Researcher"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Reymond Ngolombe",
      "orcid": "0009-0008-7624-5297"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Burnett C. Chiona"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Fikile Khangamwa Singano",
      "orcid": "0009-0001-3072-9324"
    },
    {
      "affs": [
        6
      ],
      "name": "Frank Sinyiza",
      "orcid": "0000-0002-5009-4012"
    },
    {
      "affs": [
        7
      ],
      "name": "Zizwani B. Chilinda"
    },
    {
      "affs": [
        0
      ],
      "name": "Tsae‐Jyy Wang",
      "orcid": "0000-0002-8714-5530"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/674zzdq149mga.bib",
  "cited_by": 0,
  "doi": "10.1161/jaha.125.047824",
  "fulltext_url": null,
  "id": "674zzdq149mga",
  "issns": [
    "2047-9980"
  ],
  "landing_url": "https://www.ahajournals.org/doi/10.1161/JAHA.125.047824",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ]
  ],
  "openalex": "W7222454927",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "ris": "https://research.draconitic.com/paper/674zzdq149mga.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:28Z",
      "native_id": "10.1161/jaha.125.047824",
      "source": "crossref",
      "url": "https://www.ahajournals.org/doi/10.1161/JAHA.125.047824"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2047-9980",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta‐Analysis",
  "title_text": "Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta‐Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:28Z",
  "url": "https://research.draconitic.com/paper/674zzdq149mga",
  "venue": "Journal of the American Heart Association",
  "versions": []
}