{
  "abstract": "Objective:. To describe the prevalence and detection patterns of prenatal and postnatal screening for congenital heart disease (CHD). Methods:. This retrospective cohort study was conducted at the Obstetrics and Gynecology Hospital of Fudan University between 2018 and 2020. Pregnant women with complete prenatal and postnatal follow-up data were recruited for final analysis. Prenatal and postnatal screening for CHD included mid-trimester fetal cardiac ultrasound at 20–24 gestational weeks, neonatal pulse oximetry and cardiac auscultation 6–72 hours after birth, and at a 42-day postnatal visit. Results:. Of 21,920 fetuses or neonates (including 548 twin pregnancies), 318 CHD cases were identified. The annual prevalence of CHD was 14.5 per 1000 births. CHD was associated with a higher proportion of male gender in infants, preterm birth, low birth weight, and multiple pregnancy (P < 0.001). Of the 318 CHD cases, 270 (84.9%) were simple CHD and 48 (15.1%) were complex CHD (most common was tetralogy of Fallot, coarctation of the aorta). Overall, 40.6% (129/318) of CHD cases were diagnosed prenatally, and 59.4% (189/318) were diagnosed postnatally. The prenatal diagnosis rate for complex CHD was 89.6% (43/48), whereas 68.1% (184/270) of simple CHD cases were diagnosed postnatally. The annual pattern was consistent between 2018 and 2020 (χ2 = 0.2245, P = 0.894). Conclusion:. Our findings indicate the application of a combined prenatal and postnatal screening strategy for comprehensive CHD detection. Prenatal screening for CHD achieved high levels of efficacy for complex CHD with a detection rate of 89.6%. Sequential newborn screening was crucial for identifying simple CHD with a postnatal detection rate of 68.1%. Our findings indicate that prenatal and postnatal detection pattern vary by CHD complexity.",
  "abstract_shown": true,
  "affiliations": [
    "Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China",
    "Institute of Pediatrics, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai 201102, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Li Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jialin Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiayu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jimei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiongjie Zhou"
    },
    {
      "affs": [
        1
      ],
      "name": "Yonghao Gui"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaotian Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67a473hcw59j0.bib",
  "cited_by": 0,
  "doi": "10.1097/fm9.0000000000000369",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706334/?tool=EBI",
  "id": "67a473hcw59j0",
  "issns": [
    "2096-6954",
    "2641-5895"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13706334",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RG1-991"
    ],
    [
      "openalex",
      "2713|Congenital Heart Disease Studies"
    ]
  ],
  "openalex": "W7165903631",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706334/pdf/?tool=EBI",
  "pmcid": "PMC13706334",
  "pmid": null,
  "published": "2026-06-25",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/67a473hcw59j0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:51Z",
      "native_id": "PMC:PMC13706334",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706334"
    },
    {
      "first_seen": "2026-10-30T13:43:56Z",
      "native_id": "766ae59d464b4a8ab28ebd61ca4f61d4",
      "source": "doaj",
      "url": "https://doi.org/10.1097/fm9.0000000000000369"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Congenital Heart Disease Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Prenatal and Postnatal Screening for Congenital Heart Disease: Prevalence and Detection Patterns From a Retrospective Cohort Study",
  "title_text": "Prenatal and Postnatal Screening for Congenital Heart Disease: Prevalence and Detection Patterns From a Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:56Z",
  "url": "https://research.draconitic.com/paper/67a473hcw59j0",
  "venue": "Maternal-fetal medicine (Wolters Kluwer Health, Inc.)",
  "versions": []
}