{
  "abstract": "TDP-43 proteinopathy is a hallmark of neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia where mislocalization of TDP-43 has been observed in neurons and glial cells. However, the role of TDP-43 in microglia and the consequences of its loss of function remain unexplored. Combining magnetic resonance imaging, and confocal, and electron microscopy, we uncovered structural changes and myelin abnormalities in the early postnatal brain of mice lacking microglial TDP-43. Spatial transcriptomics further revealed an enriched interferon-responsive signature associated with oligodendrocyte dysfunction. Early depletion of microglial TDP-43 led to motor deficits in adult mice. Mechanistically, knocking out TDP-43 impaired microglial ability to engulf and degrade myelin. It also led to cryptic exon inclusion in the Tyrobp mRNA, resulting in truncated DAP12 protein, thus causing defective TREM2 signaling. Our findings reveal a role for TDP-43 in regulating the TREM2-DAP12 axis in mice, highlighting a previously unrecognized mechanism through which TDP-43 controls microglial function.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "Anne-Claire Compagnion"
    },
    {
      "name": "Andranik Ivanov"
    },
    {
      "name": "Anil Rana"
    },
    {
      "name": "Felipe Espinoza"
    },
    {
      "name": "Thomas Sandmann"
    },
    {
      "name": "Fanny Martineau"
    },
    {
      "name": "Katia Monsorno"
    },
    {
      "name": "Roberta Facchinetti"
    },
    {
      "name": "Alessandro Matera"
    },
    {
      "name": "Lionel Rougé"
    },
    {
      "name": "Fernando González Ibáñez"
    },
    {
      "name": "Clarissa Catale"
    },
    {
      "name": "Matteo Bizzotto"
    },
    {
      "name": "Sonia Garel"
    },
    {
      "name": "Michela Matteoli"
    },
    {
      "name": "Yutaro Kashiwagi"
    },
    {
      "name": "Ryuta Koyama"
    },
    {
      "name": "Christian Haass"
    },
    {
      "name": "Marie-Eve Tremblay"
    },
    {
      "name": "Dieter Beule"
    },
    {
      "name": "Ileana Jelescu"
    },
    {
      "name": "Valerio Zerbi"
    },
    {
      "name": "Gilbert Di Paolo"
    },
    {
      "name": "Rosa Paolicelli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67e1xkgkdvbfj.bib",
  "cited_by": 1,
  "doi": "10.1038/s41593-026-02348-3",
  "fulltext_url": null,
  "id": "67e1xkgkdvbfj",
  "issns": [
    "1097-6256",
    "1546-1726"
  ],
  "landing_url": "https://hal.science/hal-05756431v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7167684641",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-08",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/67e1xkgkdvbfj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05756431",
      "source": "hal",
      "url": "https://hal.science/hal-05756431v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice",
  "title_text": "Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/67e1xkgkdvbfj",
  "venue": "Nature Neuroscience",
  "versions": []
}