{
  "abstract": "Adiposity-based chronic disease (ABCD) encompasses the health consequences of excess or dysfunctional adipose tissue. Selected phytochemicals have been investigated as potential adjuncts, but experimental pathway activity does not establish clinical benefit. This narrative review examines quercetin, chlorogenic acids, epigallocatechin-3-gallate (EGCG), and berberine, with other interventions providing context. The evidence was supplemented by targeted PubMed searches through 27 October 2026 and appraised according to experimental model, formulation, exposure, clinical relevance, and safety. Published pooled body-weight differences were −0.35 kg (95% confidence interval, −2.03 to 1.33) for quercetin, −1.30 kg (−2.07 to −0.52) for selected green-coffee/chlorogenic-acid interventions, −0.74 kg (−0.97 to −0.51) for green-tea preparations, and −0.88 kg (−1.36 to −0.39) for berberine. These source-specific estimates are not head-to-head comparisons. A small crossover trial of quercetin reported reduced hepatic fat, whereas a six-month berberine trial found no significant benefit for visceral or hepatic fat. Coffee and green-tea findings do not isolate the effects of chlorogenic acid or EGCG. Most mechanistic evidence remains preclinical, and differences in chemical composition, circulating metabolites, administration, and outcome selection limit translation. The human-evidence-based selection also underrepresents less-studied phytochemicals; for the evaluated interventions, sustained adiposity reduction and patient-relevant benefit remain insufficiently established. Their potential role in comprehensive ABCD care requires product-specific assessment of efficacy, exposure, adverse effects, and interactions.",
  "abstract_shown": true,
  "affiliations": [
    "Centro de Mezclas Oncológicas, Unidad Médica de Alta Especialidad No. 71, Instituto Mexicano del Seguro Social, Coahuila de Zaragoza 27000, Mexico",
    "Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68020, Mexico",
    "Instituto Mexicano del Seguro Social, Hospital General de Zona con Medicina Familiar No. 18, Coahuila de Zaragoza 27220, Mexico",
    "Secretaría de Ciencia, Humanidades, Tecnología e Innovación (SECIHTI), Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Coahuila, Coahuila de Zaragoza 25000, Mexico",
    "Secretaría de Ciencia, Humanidades, Tecnología e Innovación (SECIHTI), Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68020, Mexico",
    "División de Estudios de Posgrado e Investigación, Tecnológico Nacional de México, Instituto Tecnológico de Oaxaca, Oaxaca 68030, Mexico",
    "R&D Group, Vice Presidency for Scientific Research and Innovation, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia",
    "División de Estudios de Posgrado e Investigación, Tecnológico Nacional de México, Instituto Tecnológico de Tijuana, Tijuana 22414, Baja California, Mexico"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arguiñe Ivonne Urraza-Robledo",
      "orcid": "0000-0003-4896-4995"
    },
    {
      "affs": [
        1
      ],
      "name": "Edmar de Jesús Díaz García"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ibzan Jahzeel Salvador Ibarra",
      "orcid": "0000-0003-2053-4176"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Zoila Mora Guzmán"
    },
    {
      "affs": [
        1
      ],
      "name": "Anahí Jobeth Borrás Enríquez",
      "orcid": "0000-0003-2695-5289"
    },
    {
      "affs": [
        5
      ],
      "name": "Eduardo Pérez-Campos",
      "orcid": "0000-0001-6720-7952"
    },
    {
      "affs": [
        1
      ],
      "name": "Laura Pérez-Campos Mayoral",
      "orcid": "0000-0003-4140-4661"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniel Gómez Hernández",
      "orcid": "0009-0003-9314-7895"
    },
    {
      "affs": [
        1
      ],
      "name": "María del Socorro Pina-Canseco",
      "orcid": "0000-0002-9486-5093"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Hector Alejandro Cabrera-Fuentes",
      "orcid": "0000-0002-8502-7098"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "María Teresa Hernández-Huerta",
      "orcid": "0000-0003-2182-2540"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67efshy7ez2qd.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18213630",
  "fulltext_url": null,
  "id": "67efshy7ez2qd",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://www.mdpi.com/2072-6643/18/21/3630",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/67efshy7ez2qd.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:26:35Z",
      "native_id": "10.3390/nu18213630",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/21/3630"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2072-6643",
      "subfield": "nutrition"
    }
  ],
  "title": "Selected Dietary and Supplemental Phytochemicals in Adiposity-Based Chronic Disease: Molecular Mechanisms, Human Evidence, and Translational Gaps",
  "title_text": "Selected Dietary and Supplemental Phytochemicals in Adiposity-Based Chronic Disease: Molecular Mechanisms, Human Evidence, and Translational Gaps",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:21:09Z",
  "url": "https://research.draconitic.com/paper/67efshy7ez2qd",
  "venue": "Nutrients",
  "versions": []
}