{
  "abstract": "Alzheimer's disease (AD) staging based on amyloid-{beta}, tau, and neurodegeneration does not capture heterogeneous microglial functions. Existing transcriptomic scores indicate microglial activation or state similarity but do not resolve post-activation functions and are not directly comparable across scales. Herein, we develop a function-oriented framework comprising seven harmful-and seven adaptive-associated gene modules, selected from predefined mechanisms and direct functional evidence. Using SEA-AD micro-glia/perivascular macrophage nuclei, we compute do-nor-brain-region pseudobulk scores on a fixed P10-P90 reference scale and validate them against matched protein, activity, and tissue endpoints. H3 is related to cytokine/chemokine proteins; H4 and A5 are related to the same isoprostane readout in opposite directions; and A3 is related to dense-core plaque fraction. Benchmark comparison shows modest incremental fit but distinct out-come-specific information. In external GSE146639, eight modules remained FDR-significant, although harmful and adaptive arms are highly collinear; H7 and A2 are replicated in external proteomics. Downsampling, leave-one-gene-out, and alternative scoring analyses supports technical stability, and single-cell reconstruction supported a state-resolved basis. These scores summarize relative engagement of damage-related and adaptive programmes, enabling mechanistic comparison across donors and brain regions, but remain observational, are not intended for clinical decision-making, and require further validation.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Institute of Technology"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "A. Tu"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67ghbzv5epm42.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.759278",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759278v1.full",
  "id": "67ghbzv5epm42",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759278v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7223123596",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759278v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/67ghbzv5epm42.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:51Z",
      "native_id": "10.64898/2026.10.14.759278",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759278v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Function-oriented microglial transcriptional scores in Alz-heimer's disease: resolving terminal functions beyond activa-tion states",
  "title_text": "Function-oriented microglial transcriptional scores in Alz-heimer's disease: resolving terminal functions beyond activa-tion states",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:51Z",
  "url": "https://research.draconitic.com/paper/67ghbzv5epm42",
  "venue": "bioRxiv",
  "versions": []
}