{
  "abstract": "The microRNA-200 family (miR-200s) is known for inhibiting epithelial-to-mesenchymal transition and cell-cycle progression in cancer, but its function in epithelial development remains unclear. Here we show that miR-200s are highly enriched in hair matrix progenitors but absent from the upper hair follicle (HF), where sebaceous gland (SG) and HF stem cells are specified. Ectopic miR-200 induction abolishes SG specification while preserving hair morphogenesis. Genome-wide identification of miR-200 targets reveals direct repression of negative regulators of WNT signaling and cell-cycle regulators. Single-cell and spatial transcriptomic analyses uncover mutually exclusive domains of WNT activity and SOX9 expression in the upper HF that is disrupted by miR-200 induction. Genome-wide mapping of SOX9 targets further uncovers a lipogenic and fatty-acid metabolic program required for SG specification. Together, these findings show that miR-200 blocks SG fate by inhibiting SOX9 function and restricting cell proliferation, defining a spatially organized regulatory network essential for SG development.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Arpan Das",
      "orcid": "0000-0001-7890-4884"
    },
    {
      "name": "Yuheng C. Fu",
      "orcid": "0000-0001-8037-6398"
    },
    {
      "name": "Haimin Li"
    },
    {
      "name": "Megan A. Wong"
    },
    {
      "name": "Annalina Che"
    },
    {
      "name": "Anumeha Singh"
    },
    {
      "name": "Jimin Han"
    },
    {
      "name": "Glen Bjerke"
    },
    {
      "name": "Dongmei Wang",
      "orcid": "0000-0002-3923-8951"
    },
    {
      "name": "Rui Yi",
      "orcid": "0000-0002-6934-7091"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67n2r4ajrehcy.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77136-5",
  "fulltext_url": null,
  "id": "67n2r4ajrehcy",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77136-5",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2748|Hair Growth and Disorders"
    ]
  ],
  "openalex": "W7222601398",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77136-5_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/67n2r4ajrehcy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-77136-5",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77136-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Hair Growth and Disorders",
      "subfield": "general"
    }
  ],
  "title": "Coordinated inhibition of SOX9 and cell-cycle progression by microRNA-200 restricts sebaceous gland fate specification",
  "title_text": "Coordinated inhibition of SOX9 and cell-cycle progression by microRNA-200 restricts sebaceous gland fate specification",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/67n2r4ajrehcy",
  "venue": "Nature Communications",
  "versions": []
}