{
  "abstract": "AIMS: Lipoprotein(a) (Lp(a)) is a strong risk factor for cardiovascular events, independent of low-density lipoprotein cholesterol (LDL-C). Because the Lp(a) concentration is largely determined by genetic factors, some dyslipidemia guidelines recommend a once-in-a-lifetime measurement of Lp(a). Furthermore, a non-fasting lipid profile assessment is allowed for initial screening of dyslipidemia. Although the LDL-C concentration decreases slightly throughout the day, the within-day variation of Lp(a) remains unknown. We aimed to investigate whether the Lp(a) concentration remains stable throughout the day. METHODS: Lp(a) concentrations were measured at seven time points throughout the day in 34 patients using a latex turbidimetric immunoassay. The Lp(a) values are expressed in molar units, which are equivalent to those determined by a mass spectrometry-based reference measurement procedure. RESULTS: We found that the Lp(a) concentrations decreased by 2.9±5.2 nmol/L at 14:00 (p＜0.05), 3.6±4.8 nmol/L at 20:00 (p＜0.001), and 2.9±5.1 nmol/L at 24:00 (p＜0.05). The mean percent Lp(a) decreased significantly at 17:30 (-6.2±0.1%) and 24:00 (-7.0±0.1%) from the fasting level. CONCLUSION: The Lp(a) concentration decreases slightly, but significantly, throughout the day. Considering physiological variations, it is preferable to re-evaluate the Lp(a) concentration in those with a borderline elevation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Shuxin Song"
    },
    {
      "name": "Satoshi Hirayama"
    },
    {
      "name": "Haruka Inaba"
    },
    {
      "name": "Atsushi Hori"
    },
    {
      "name": "Yuna Horiuchi"
    },
    {
      "name": "Yuri Ichikawa"
    },
    {
      "name": "Yutaka Kimura"
    },
    {
      "name": "Yoshifumi Fukushima"
    },
    {
      "name": "Tsuyoshi Ueno"
    },
    {
      "name": "Yuki Uehara"
    },
    {
      "name": "Takashi Miida"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67n9rhnz1sem4.bib",
  "cited_by": 0,
  "doi": "10.5551/jat.66290",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66290/_article",
  "id": "67n9rhnz1sem4",
  "issns": [
    "1880-3873",
    "1340-3478"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66290/_article",
  "language": null,
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7221643545",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66290/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/67n9rhnz1sem4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.5551/jat.66290",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66290/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Physiological within-day Variation in Lipoprotein(a): Is a Once-in-a-lifetime Measurement Sufficient for Cardiovascular Risk Evaluation?",
  "title_text": "Physiological within-day Variation in Lipoprotein(a): Is a Once-in-a-lifetime Measurement Sufficient for Cardiovascular Risk Evaluation?",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/67n9rhnz1sem4",
  "venue": "Journal of Atherosclerosis and Thrombosis",
  "versions": []
}