{
  "abstract": "Soft tissue defects require the application of adipose tissue reconstruction techniques; however, these approaches often face challenges such as low survival rates due to mechanical pressure and inadequate blood supply. This study presents the development of an injectable, self-healing polysaccharide hydrogel designed for the slow release of basic fibroblast growth factor (b-FGF) that utilizes oxidized hyaluronic acid (OHA) and carbohydrazide-modified gelatin (Gel-CDH) as foundational components. The hydrogel is characterized by an optimal pore size, porosity, mechanical properties, and degradation behavior, in addition to excellent biocompatibility, all of which facilitate adipose tissue growth. In vitro experiments revealed that the OHA/Gel-CDH polysaccharide hydrogel significantly enhanced the adipogenic differentiation of adipose-derived stem cells. Furthermore, the implantation of the polysaccharide hydrogel in conjunction with an autologous fat graft suspension into the subcutaneous of the rat dorsal region resulted in improved adipose tissue survival and the regeneration of vascularized adipose tissue. These results suggest that the use of an injectable, self-healing OHA/Gel-CDH polysaccharide hydrogel with slow-released b-FGF in combination with autologous fat grafting is a promising strategy for the repair of soft tissue defects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgical Oncology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China.",
    "Department of Surgical Oncology, 3201 Hospital, Hanzhong, Shaanxi, 723000, China.",
    "College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi, 710021, China.",
    "Department of General Surgery, Ankang Hospital of Traditional Chinese Medicine, Ankang, Shaanxi, 725000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuhan Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Wenjun Shu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xulong Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yong Mei Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhenxiu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Wang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hengtao Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Dong Xiao"
    },
    {
      "affs": [
        1
      ],
      "name": "Chao Zhai"
    },
    {
      "affs": [
        0
      ],
      "name": "Nan Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianhui Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67nccnd089zjj.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103739",
  "fulltext_url": "https://europepmc.org/articles/PMC13682190",
  "id": "67nccnd089zjj",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903678",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7221008616",
  "pdf_url": "https://europepmc.org/articles/PMC13682190?pdf=render",
  "pmcid": "PMC13682190",
  "pmid": "42903678",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/67nccnd089zjj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903678",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903678"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Hydrogels: synthesis, properties, applications",
      "subfield": "general"
    }
  ],
  "title": "Injectable self-healing polysaccharide hydrogel with slow-release b-FGF for adipose tissue regeneration.",
  "title_text": "Injectable self-healing polysaccharide hydrogel with slow-release b-FGF for adipose tissue regeneration.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/67nccnd089zjj",
  "venue": "Materials today. Bio",
  "versions": []
}