{
  "abstract": "Small nucleolar RNAs (snoRNAs) are single-stranded non-coding RNAs found in eukaryotic nucleolus, and their aberrant expression is closely related to tumorigenesis. Box C/D SNORD116-17, a member of SNORD116 cluster, is highly expressed in prostate cancer tissues, though its biological function in this malignancy remains uncharacterized. Here, we found that SNORD116-17 is evident, stable, and highly expressed in prostate cancer cells and that its overexpression significantly promoted the proliferation, migration, and invasion of cancer cells. Bioinformatics prediction, RIP, RNA dot blot, and RNA-protein pulldown experiments revealed that miR-206 interacted with SNORD116-17, forming a complex with Argonaute 2. Subsequently, PCR and western blot experiments revealed that both miR-206 and SNORD116-17 regulated the expression of E2F transcription factor 5 (E2F5), a commonly studied oncogene in prostate cancer. In summary, SNORD116-17 contributes to prostate cancer progression by sponging with miR-206 through the ceRNA mechanism and upregulating the expression of E2F5.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Xiuyi Pan",
      "orcid": "0000-0003-1918-3209"
    },
    {
      "name": "Yifan Kang"
    },
    {
      "name": "Jinjing Zhong"
    },
    {
      "name": "Ting Yu"
    },
    {
      "name": "Linmao Zheng"
    },
    {
      "name": "Yuyan Wei"
    },
    {
      "name": "Junya Tan"
    },
    {
      "name": "Ling Nie"
    },
    {
      "name": "Mengni Zhang"
    },
    {
      "name": "Ni Chen"
    },
    {
      "name": "Qiao Zhou"
    },
    {
      "name": "Xueqin Chen",
      "orcid": "0000-0002-3165-4280"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67s0ey8k3d6tt.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117806",
  "fulltext_url": "https://europepmc.org/articles/PMC13677326",
  "id": "67s0ey8k3d6tt",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03187-1",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "biochemistry"
    ],
    [
      "heading",
      "biological sciences"
    ],
    [
      "heading",
      "cancer"
    ],
    [
      "heading",
      "molecular biology"
    ],
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7221044826",
  "pdf_url": "https://europepmc.org/articles/PMC13677326?pdf=render",
  "pmcid": "PMC13677326",
  "pmid": "42898100",
  "published": "2026-10-08",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/67s0ey8k3d6tt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117806",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03187-1"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117806",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226031871"
    },
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898100",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898100"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:molecular biology",
      "subfield": "molecular-biology"
    },
    {
      "field": "medicine",
      "origin": "heading:cancer",
      "subfield": "oncology"
    }
  ],
  "title": "Box C/D SNORD116-17 promotes prostate cancer progression by targeting the miR-206/E2F5 axis",
  "title_text": "Box C/D SNORD116-17 promotes prostate cancer progression by targeting the miR-206/E2F5 axis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/67s0ey8k3d6tt",
  "venue": "iScience",
  "versions": []
}