{
  "abstract": "Background and objectivesIndustrialisation is associated with lower gut microbial richness. The ecological insurance hypothesis proposes that richer communities buffer disturbance via overlapping functions, possibly affecting infection susceptibility. We state predictions, audit the evidence, and test the richness-infection relationship in Gambian children.\n\nMethodologyWe analysed 452 children aged 6-35 months with Day 85 stool 16S profiles and dated infections over 113 days. Diversity used Hill numbers (q = 0, 1, 2); redundancy was inferred from reference-genome gene content. We examined associations with illness during follow-up and infections after Day 85, adjusting for earlier illness.\n\nResultsRichness was lower in children with any infection (93.9 vs 103.1; d = 0.36; adjusted odds ratio 0.989 per species, p = 0.019); abundance-weighted diversity was not. Most illness preceded sampling (295 of 315); the difference lay in common and intermediate-prevalence species. Richness was lowest around recent illness. Higher richness was associated with fewer later infections (rate ratio 0.69 per SD, 95% CI 0.51-0.93; q = 0.11). Redundancy correlated with richness at q = 0 ({rho} = 0.93); at q = 1-2 estimates indicated lower infection rates but none survived correction (smallest FDR q = 0.14).\n\nConclusions and implicationsRichness and infection were associated in both directions: children who had been ill had lower richness, and greater Day 85 diversity preceded fewer infections. Redundancy was directionally aligned with reduced infection at higher diversity orders, but FDR control and collinearity limit inference. Cohorts sampled before illness, with shotgun data, are needed.\n\nLay summaryGambian toddlers who had been ill had fewer kinds of gut bacteria than those who stayed well. Diversity was lowest around recent illness. Children with more diverse gut communities also experienced fewer infections afterwards. Functional redundancy generally showed the same direction of association, but its contribution beyond richness remains uncertain.",
  "abstract_shown": true,
  "affiliations": [
    "MRC @ LSHTM"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "O. N. Ofordile"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/67w0cp0rxaz0g.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.06.26364910",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.06.26364910v1.full",
  "id": "67w0cp0rxaz0g",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.06.26364910v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7220964513",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.06.26364910v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/67w0cp0rxaz0g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.64898/2026.10.06.26364910",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.06.26364910v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Does gut microbial richness lost with industrialisation matter for infection? A two-direction test in Gambian toddlers",
  "title_text": "Does gut microbial richness lost with industrialisation matter for infection? A two-direction test in Gambian toddlers",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/67w0cp0rxaz0g",
  "venue": "medRxiv",
  "versions": []
}