{
  "abstract": "To fill the gap in the synthesis of polychlorinated biphenyl isotope internal standard reagents in China，this study investigates the synthesis and characterization method of stable isotope-labeled 2,3,3’,4,4’,5-hexachlorobiphenyl-2’,6,6’-D3. Using 1,2,3,4-tetrachlorobenzene-D2 as the starting material，the intermediate 1,2,3,4-tetrachloroiodobenzene-D was obtained via iodination. Meanwhile，using 3,4-dichloroaniline as the material，3,4-dichlorophenylboronic acid pinacol ester-2,6-D2 was synthesized through three steps: hydrogen/deuterium exchange，diazotization iodination，and boration. The target product 2,3,3’,4,4’,5-hexachlorobiphenyl-2’,6,6’-D3 was obtained via Suzuki coupling of the two intermediates. According to the amount of 1,2,3,4-tetrachlorobenzene-D2，the overall yield of this synthetic route was 31.14%. The structure of the target product was characterized by 1H NMR，gas chromatography and mass spectrometry. The chemical purity of the product was 99.04% and the abundance of deuterium isotope was 99.17 atom%D，and it can be used as a standard reference material for the detection of polychlorinated biphenyls.",
  "abstract_shown": true,
  "affiliations": [
    "Anpel Laboratory Technologies (Shanghai) Inc., Shanghai 201600, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rong WANG"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui GUO"
    },
    {
      "affs": [
        0
      ],
      "name": "Wulian CHEN"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/681m2askk8snh.bib",
  "cited_by": 0,
  "doi": "10.7538/tws.2026.youxian.049",
  "fulltext_url": "https://tws.xml-journal.net/article/doi/10.7538/tws.2026.youxian.049",
  "id": "681m2askk8snh",
  "issns": [
    "1000-7512"
  ],
  "landing_url": "https://doi.org/10.7538/tws.2026.youxian.049",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QC770-798"
    ],
    [
      "openalex",
      "3003|Chemical Reactions and Isotopes"
    ]
  ],
  "openalex": "W7224082980",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Editorial Board of Journal of Isotopes",
  "ris": "https://research.draconitic.com/paper/681m2askk8snh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:15Z",
      "native_id": "f4b6d2e840ce4fcab770b8424871259f",
      "source": "doaj",
      "url": "https://doi.org/10.7538/tws.2026.youxian.049"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Chemical Reactions and Isotopes",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Synthesis and Characterization of Stable Isotope Labeled 2,3,3’,4,4’,5-Hexachlorobiphenyl-2’,6,6’-D3",
  "title_text": "Synthesis and Characterization of Stable Isotope Labeled 2,3,3’,4,4’,5-Hexachlorobiphenyl-2’,6,6’-D3",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:15Z",
  "url": "https://research.draconitic.com/paper/681m2askk8snh",
  "venue": "Journal of Isotopes",
  "versions": []
}