{
  "abstract": "Background: Patient-centred care increasingly encourages patients to participate in decisions regarding their anaesthetic management. However, whether expressing a preference regarding their anaesthetic management is associated with improved postoperative recovery remains unknown. We evaluated the association between preference expression and quality of recovery after noncardiac surgery.\n\nMethods: In this prospective partially randomised patient-preference study conducted at two academic hospitals, adults undergoing minimally invasive abdominal, urologic, or gynaecologic surgery received standardised information on opioid-based and opioid-free anaesthesia, co-developed with patient partners. Participants expressing a preference received their preferred strategy, whereas those without a preference were randomised 1:1 to either strategy. The primary outcome was the Quality of Recovery-15 (QoR-15) score on postoperative day (POD) 1.\n\nResults: Among 220 analysed participants, 177 (80.5%) expressed a preference, and 43 (19.5%) underwent random allocation. Mean [standard deviation] QoR-15 scores on POD 1 were higher among participants expressing a preference than among randomised participants (108.8 [18.2] vs 100.8 [23.5]), with an unadjusted mean difference of 7.9 points (95% confidence interval [CI] 1.5–14.4; P=0.017). The adjusted marginal mean difference was 7.1 points (95% CI 0.3–13.9; P=0.042). Scores on the QoR-15 also remained higher on POD 2. Sensitivity analyses showed consistent effect estimates but attenuated statistical significance. Secondary outcomes, including postoperative nausea and vomiting and bradycardia, were similar between groups.\n\nConclusions: Expression of a preference regarding intraoperative opioid management was associated with better reported early postoperative patient-reported recovery. Given the non-randomised comparison and limited precision, -generating and support further investigation into the role of patient-preference expression in perioperative recovery.\n\nTrial registration: The full, long-term study is pre-registered at ClinicalTrials.gov (identifier, NCT06855641; first posted, 3 March 2025; Alexandre Joosten). https://clinicaltrials.gov/study/NCT06855641.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anaesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA",
    "Department of Anaesthesiology and Perioperative Medicine, Nîmes University Hospital, Nîmes, France",
    "IMAGINE UR UM 103, Montpellier University, Anaesthesia Critical Care, Emergency and Pain Medicine Division, Nîmes University Hospital, Nîmes, France",
    "Department of Medicine Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA",
    "Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, Aberdeen, UK",
    "Anaesthesia Department, NHS Grampian, Aberdeen, UK",
    "Pain and Opioids After Surgery (PANDOS) European Society of Anaesthesiology and Intensive Care (ID ESAIC_RG_PAND) Research Group, Brussels, Belgium"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yann Gricourt"
    },
    {
      "affs": [
        0
      ],
      "name": "Nancy M. Boulos"
    },
    {
      "affs": [
        0
      ],
      "name": "Amelie Delaporte"
    },
    {
      "affs": [
        0
      ],
      "name": "Maziar M. Nourian"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel Pearce"
    },
    {
      "affs": [
        0
      ],
      "name": "Ido Neuman"
    },
    {
      "affs": [
        0
      ],
      "name": "Reza Borna"
    },
    {
      "affs": [
        0
      ],
      "name": "Josue Chirinos"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenneth Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Justin Mitchell"
    },
    {
      "affs": [
        0
      ],
      "name": "Sebastian Kahf"
    },
    {
      "affs": [
        0
      ],
      "name": "Theodora Wingert"
    },
    {
      "affs": [
        3
      ],
      "name": "Tristan Grogan"
    },
    {
      "affs": [
        0
      ],
      "name": "David Boldt"
    },
    {
      "affs": [
        0
      ],
      "name": "Maxime Cannesson"
    },
    {
      "affs": [
        2,
        4,
        5,
        6
      ],
      "name": "Patrice Forget"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexandre Joosten"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68c8d4mnb7qm2.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bjao.2026.100867",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734914/",
  "id": "68c8d4mnb7qm2",
  "issns": [
    "2772-6096"
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  "landing_url": "https://doi.org/10.1016/j.bjao.2026.100867",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
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      "2703|Anesthesia and Pain Management"
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  "openalex": "W7223702856",
  "pdf_url": null,
  "pmcid": "PMC13734914",
  "pmid": "42990960",
  "published": "2026-10-26",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/68c8d4mnb7qm2.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:43Z",
      "native_id": "PMC13734914",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "Patient preference for intraoperative opioid strategy and early postoperative recovery after noncardiac surgery: a prospective partially randomised patient-preference trial (the PERFECT trial)",
  "title_text": "Patient preference for intraoperative opioid strategy and early postoperative recovery after noncardiac surgery: a prospective partially randomised patient-preference trial (the PERFECT trial)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:43Z",
  "url": "https://research.draconitic.com/paper/68c8d4mnb7qm2",
  "venue": "BJA Open",
  "versions": []
}