{
  "abstract": "Objective\n\nTo investigate the association between TRMT9B expression and clinicopathological features in thyroid carcinoma.Methods\n\nTRMT9B mRNA expression was analyzed using The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) and Genotype-Tissue Expression (GTEx) datasets as well as six independent Gene Expression Omnibus (GEO) datasets. Protein-level data were obtained from The Human Protein Atlas. Associations between TRMT9B expression and clinicopathological parameters were evaluated in the TCGA cohort.Results\n\nTRMT9B mRNA was significantly downregulated in thyroid tumors compared with normal tissues across multiple cohorts. In the TCGA cohort, lower TRMT9B expression was significantly correlated with advanced T stage, lymph node involvement, and aggressive histological variants of papillary thyroid carcinoma. Immunohistochemistry data qualitatively supported these findings: protein staining was lower in tumor samples than in healthy tissue.Conclusion\n\nTRMT9B is downregulated in thyroid carcinoma and is associated with markers of disease progression. These findings suggest that TRMT9B plays a role in thyroid tumor biology. Further functional studies are required to clarify its mechanisms and potential clinical utility as a biomarker.",
  "abstract_shown": true,
  "affiliations": [
    "Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.",
    "Laboratório de Hormônios e Genética Molecular LIM/42, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.",
    "Institute of Biomedical Sciences, Department of Cell and Developmental Biology, Universidade de São Paulo, São Paulo, SP, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isadora Biazon de Souza",
      "orcid": "0009-0000-8328-5694"
    },
    {
      "affs": [
        0
      ],
      "name": "Larissa Mikalauskas",
      "orcid": "0009-0009-3670-2542"
    },
    {
      "affs": [
        0
      ],
      "name": "Felipe Yuji Koyama Azeka",
      "orcid": "0009-0009-5550-1797"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexander de Moraes Frankiw",
      "orcid": "0009-0001-9399-116X"
    },
    {
      "affs": [
        0
      ],
      "name": "Nathan Mignella Greco",
      "orcid": "0009-0006-1266-5597"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Alice Kawashita Dalla Vecchia",
      "orcid": "0009-0003-9100-177X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Helena Panteliou Lima-Valassi",
      "orcid": "0000-0002-5292-2571"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Alessandra Valéria de Sousa Faria",
      "orcid": "0000-0003-1161-5724"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68cbgft3ajd01.bib",
  "cited_by": 0,
  "doi": "10.31744/einstein_journal/2026ao2165",
  "fulltext_url": "https://europepmc.org/articles/PMC13682766",
  "id": "68cbgft3ajd01",
  "issns": [
    "1679-4508",
    "2317-6385"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912012",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Thyroid Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222322741",
  "pdf_url": "https://europepmc.org/articles/PMC13682766?pdf=render",
  "pmcid": "PMC13682766",
  "pmid": "42912012",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/68cbgft3ajd01.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912012",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912012"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Thyroid Cancer Diagnosis and Treatment",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Downregulation of TRMT9B and its association with clinicopathological features in thyroid cancer: an analysis of public datasets.",
  "title_text": "Downregulation of TRMT9B and its association with clinicopathological features in thyroid cancer: an analysis of public datasets.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/68cbgft3ajd01",
  "venue": "Einstein (Sao Paulo, Brazil)",
  "versions": []
}