{
  "abstract": "Bone tissue engineering utilizing bioactive materials represents a promising strategy for regenerating bone defects and stimulating new tissue growth. In this study, a biocompatible, bone-mimicking material was developed by incorporating the arginine–glycine–aspartate (RGD) amino motif onto the surface of a titanium-based metal–organic framework (MOF), MIL-125, using a simple solvent-soaking method to impart osteoinductive properties. The molecular incorporation, phase composition, and surface morphology of the functionalized MIL-125 powder were comprehensively characterized using microdifferential scanning calorimetry (Micro-DSC), XRD, SEM, EDX, and FT-IR. Among the investigated conditions, the MIL-125 sample prepared with 0.25 mg of RGD and a 36 h soaking time exhibited the most favorable physicochemical characteristics based on the combined structural, spectroscopic, thermal, elemental, and morphological analyses. SEM analysis revealed the initial development of needle-like RGD-associated structures at 0.15 mg of RGD, which was consistent with the appearance of an exothermic Micro-DSC peak associated with RGD interaction with the MIL-125 surface. Furthermore, quantum chemical calculations were performed to elucidate the molecular-level interaction mechanisms between the peptide and the MOF framework. The computational results uncovered two stable adsorption configurations within the MIL-125 pore structure. Among these, the aspartic acid (ASP)-terminal-coordinated titanium oxide cluster of MIL-125 exhibited the highest thermodynamic stability, possessing an adsorption energy of −24.99 kcal/mol, which was more than 2-fold stronger than the arginine (ARG)-terminal interaction. This strong electronic binding corroborates the experimentally observed RGD immobilization. Ultimately, these fundamental insights into RGD–MOF chemical interactions provide a robust framework for developing advanced bioactive components suitable for orthopedic regeneration applications.",
  "abstract_shown": true,
  "affiliations": [
    "Prince of Songkla University , , , ,",
    "Walailak University , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pemikar Srifa"
    },
    {
      "affs": [
        0
      ],
      "name": "Si Thu Myint Maung"
    },
    {
      "affs": [
        0
      ],
      "name": "Dhassida Sooksawat"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuwanda Injongkol",
      "orcid": "0009-0001-3183-0096"
    },
    {
      "affs": [
        0
      ],
      "name": "Kantida Juncheed"
    },
    {
      "affs": [
        0
      ],
      "name": "Kantapon Dissaneewate"
    },
    {
      "affs": [
        0
      ],
      "name": "Jirut Meesane",
      "orcid": "0000-0002-6242-818X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68p582cfhtk1h.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c08486",
  "fulltext_url": null,
  "id": "68p582cfhtk1h",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08486/5465912/Ti-Based-Template-Incorporated-with-RGD-Amino",
  "language": null,
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c08486",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/68p582cfhtk1h.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T00:21:06Z",
      "native_id": "10.1021/acsomega.6c08486",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c08486/5465912/Ti-Based-Template-Incorporated-with-RGD-Amino"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:2470-1343",
      "subfield": "general"
    }
  ],
  "title": "Ti-Based Template Incorporated with RGD Amino Motif as a Domain Supporting Self-Assembly of Extracellular Matrix in Bone Tissue Regeneration: Preparation, Characterization, and Correlated Structure to Identified Application",
  "title_text": "Ti-Based Template Incorporated with RGD Amino Motif as a Domain Supporting Self-Assembly of Extracellular Matrix in Bone Tissue Regeneration: Preparation, Characterization, and Correlated Structure to Identified Application",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:21:54Z",
  "url": "https://research.draconitic.com/paper/68p582cfhtk1h",
  "venue": "ACS Omega",
  "versions": []
}