{
  "abstract": "Introduction and importance:: Primary colonic lymphoma (PCL) is a rare extranodal manifestation of non-Hodgkin lymphoma, accounting for a small fraction of colorectal malignancies. Due to its low incidence and nonspecific clinical and radiological features, PCL is frequently misdiagnosed as colonic adenocarcinoma. Optimal management remains poorly defined, and current treatment strategies rely on retrospective data and expert consensus.\n\nCase presentation:: We report the case of a 69-year-old woman who presented with right lower quadrant abdominal pain and was found to have a near-obstructing ascending colon mass with extensive regional and retroperitoneal lymphadenopathy on computed tomography. Colonoscopic biopsies were nondiagnostic despite a malignant-appearing lesion. Given impending obstruction, the patient underwent an open right hemicolectomy with primary anastomosis. Histopathologic and immunohistochemical analysis of the surgical specimen revealed diffuse large B-cell lymphoma (DLBCL). Postoperative staging with positron emission tomography demonstrated fluorodeoxyglucose-avid nodal disease. The patient was treated with adjuvant immunochemotherapy and radiotherapy, achieving a complete metabolic response on follow-up imaging.\n\nClinical discussion:: This case highlights the diagnostic challenges of PCL and emphasizes the importance of surgical resection in symptomatic patients for both definitive diagnosis and management. DLBCL is the most common PCL subtype and responds favorably to multimodal therapy, including rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone–based chemotherapy. Positron-emission tomography–computed tomography plays a critical role in staging and assessment of treatment response.\n\nConclusion:: PCL should be considered in the differential diagnosis of colonic masses, particularly when biopsy results are inconclusive. A multidisciplinary, multimodal treatment approach can lead to favorable outcomes. Further prospective studies are needed to establish standardized management guidelines.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Hudson Regional Health, Bayonne, NJ, USA",
    "Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Konstantina Kostara"
    },
    {
      "affs": [
        0
      ],
      "name": "Brandon Velazquez",
      "orcid": "0009-0009-0078-6481"
    },
    {
      "affs": [
        1
      ],
      "name": "Samantha Walkow"
    },
    {
      "affs": [
        0
      ],
      "name": "Tiffany Battagliola"
    },
    {
      "affs": [
        0
      ],
      "name": "Zbigniew Moszczynski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68r1z5bw9t249.bib",
  "cited_by": 0,
  "doi": "10.1097/rc9.0000000000001081",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13747476/",
  "id": "68r1z5bw9t249",
  "issns": [
    "2210-2612"
  ],
  "landing_url": "https://doi.org/10.1097/rc9.0000000000001081",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7225724989",
  "pdf_url": "https://europepmc.org/articles/PMC13747476?pdf=render",
  "pmcid": "PMC13747476",
  "pmid": "43006029",
  "published": "2026-10-06",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/68r1z5bw9t249.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T12:23:32Z",
      "native_id": "PMC13747476",
      "source": "pmc",
      "url": "https://doi.org/10.1097/rc9.0000000000001081"
    },
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43006029",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43006029"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Primary colonic lymphoma as an uncommon cause of large bowel obstruction: a case report",
  "title_text": "Primary colonic lymphoma as an uncommon cause of large bowel obstruction: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:24:20Z",
  "url": "https://research.draconitic.com/paper/68r1z5bw9t249",
  "venue": "International Journal of Surgery Case Reports",
  "versions": []
}