{
  "abstract": "Mutation spectra vary among populations, and a comprehensive view of this variation requires broad sampling and fine-scale population resolution. Here, we profile mutation spectra from single-nucleotide polymorphisms and small insertions and deletions in a uniformly processed collection of 3,034 globally sampled Saccharomyces cerevisiae genomes, and an extended dataset including the previously sampled global 1,011-genome collection. Major mutation spectrum patterns reported from the 1,011 genomes remain evident in the extended dataset, including the pronounced mutation-spectrum differentiation of African Beer strains. At finer population resolution, we identify additional variation among wine-associated populations, including a Georgian Wine-associated signal that is strongest among rare variants and is therefore consistent with a comparatively recent change in mutation processes. We further apply a sequence-context-aware classification to characterize small-indel profiles across the 3,034 natural yeast genomes. Together, our analyses show that expanded sampling and refined population assignments provide a more comprehensive view of mutation-spectrum variation within S. cerevisiae.",
  "abstract_shown": true,
  "affiliations": [
    "Arizona State University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "C. Wheeler"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68xmd57tf2qaj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.28.755217",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.755217v1.full",
  "id": "68xmd57tf2qaj",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.755217v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "evolutionary biology"
    ],
    [
      "openalex",
      "1312|Fungal and yeast genetics research"
    ]
  ],
  "openalex": "W7214887434",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.755217v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/68xmd57tf2qaj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:29Z",
      "native_id": "10.64898/2026.09.28.755217",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.28.755217v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:evolutionary biology",
      "subfield": "evolutionary-biology"
    }
  ],
  "title": "Mutation spectra across 3,034 Saccharomyces cerevisiae genomes distinguish the Georgian Wine population",
  "title_text": "Mutation spectra across 3,034 Saccharomyces cerevisiae genomes distinguish the Georgian Wine population",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:29Z",
  "url": "https://research.draconitic.com/paper/68xmd57tf2qaj",
  "venue": "bioRxiv",
  "versions": []
}