{
  "abstract": "Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and its molecular pathogenesis is not fully understood. This exploratory study investigated the expression of three selected microRNAs in colorectal cancer and their associations with previously characterized ADAM transcripts. RT-qPCR was used to assess miR-125b-5p, miR-338-3p, and miR-30c-5p in paired tumor and histologically tumor-free surgical margin tissues from 67 patients. Previously obtained ADAM10, ADAM12, ADAM17, and ADAM28 transcript data from the same cohort were included in correlation analyses. The Wilcoxon signed-rank test and Spearman’s rank correlation were applied, with Benjamini–Hochberg adjustment for multiple testing. MiR-125b-5p expression was lower in tumors than in matched margins (median 0.46 versus 1.33; adjusted p = 0.035). No significant paired differences were identified for miR-338-3p or miR-30c-5p. Margin miR-125b-5p expression was associated with neoadjuvant-treatment history (adjusted p = 0.033), although the treated subgroup was small. No miRNA-ADAM transcript correlations remained significant after adjustment. Positive correlations among some miRNA pairs were observed within tumor and margin tissues. The reduced level of relative miR-125b-5p expression in colorectal cancers is an observational finding consistent with the tumor-suppressor functions described in the literature, but it does not constitute proof of those functions. Inter-miRNA correlations do not demonstrate shared regulatory mechanisms, and the absence of miRNA-ADAM transcript associations does not exclude post-transcriptional regulation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Metabolic Disease Prevention, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland",
    "Department of Clinical Oncology, No. 4 Provincial Specialist Hospital, 41-902 Bytom, Poland",
    "Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-808 Zabrze, Poland",
    "Department of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-514 Katowice, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Agnieszka Kalita",
      "orcid": "0000-0002-1065-4978"
    },
    {
      "affs": [
        1
      ],
      "name": "Magdalena Sikora-Skrabaka",
      "orcid": "0000-0003-1143-1423"
    },
    {
      "affs": [
        2
      ],
      "name": "Karolina Gołąbek",
      "orcid": "0000-0002-0042-5856"
    },
    {
      "affs": [
        2
      ],
      "name": "Krzysztof Biernacki",
      "orcid": "0000-0002-2620-3880"
    },
    {
      "affs": [
        2
      ],
      "name": "Joanna Katarzyna Strzelczyk"
    },
    {
      "affs": [
        3
      ],
      "name": "Dariusz Waniczek",
      "orcid": "0000-0002-0410-8604"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ewa Nowakowska-Zajdel",
      "orcid": "0000-0003-3941-7308"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/68zjr309h7jwt.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219983",
  "fulltext_url": null,
  "id": "68zjr309h7jwt",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9983",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/68zjr309h7jwt.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:27Z",
      "native_id": "10.3390/ijms27219983",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9983"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Expression and Co-Expression Patterns of Selected MicroRNAs and ADAM Genes in Colorectal Cancer",
  "title_text": "Expression and Co-Expression Patterns of Selected MicroRNAs and ADAM Genes in Colorectal Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:27Z",
  "url": "https://research.draconitic.com/paper/68zjr309h7jwt",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}