{
  "abstract": "Background/Objectives: Pediatric guidelines retain induced hypothermia as an option, but its optimal duration is uncertain. We compared survival and favorable neurologic outcomes across duration-specific strategies. Methods: Five databases and ClinicalTrials.gov were searched through 20 August 2026. A random-effects network meta-analysis compared 24, 48, and 72 h hypothermia (HT) with heterogeneous Control strategies. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool and the Risk Of Bias In Non-randomized Studies of Interventions tool; certainty was assessed using Confidence in Network Meta-Analysis (CINeMA). Results: Survival included five studies (three randomized, two observational; 785 participants), and neurologic outcomes included four (three randomized, one observational; 615 participants). HT-72 h was associated with higher survival than Control (risk ratio [RR], 2.01; 95% confidence interval [CI], 1.24–3.25); 72% of this estimate derived from one observational study measuring 1-month survival, versus 12 months in the randomized 48 h trials. The estimate versus HT-48 h (RR, 1.77; 95% CI, 1.05–2.97) was entirely indirect and depended on merging different Control strategies. The neurologic estimate versus Control (RR, 10.92; 95% CI, 1.32–90.40) depended on a single observational study at serious risk of bias and was extremely imprecise. Superiority over shorter durations was not robust. Certainty for HT-72 h versus Control was very low for both outcomes. Conclusions: Evidence remains compatible with equipoise and does not establish an optimal duration. Funding: No external funding. Registration: Open Science Framework, 10.17605/OSF.IO/9MNDB (retrospective).",
  "abstract_shown": true,
  "affiliations": [
    "Department of Emergency Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of Korea"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinpyo Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Tae Nyoung Chung",
      "orcid": "0000-0003-3537-4136"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/690vh3wnfgrcq.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218364",
  "fulltext_url": null,
  "id": "690vh3wnfgrcq",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8364",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2711|Cardiac Arrest and Resuscitation"
    ]
  ],
  "openalex": "W7224017453",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/690vh3wnfgrcq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218364",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8364"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Cardiac Arrest and Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Duration of Induced Hypothermia After Pediatric Cardiac Arrest: A Systematic Review and Network Meta-Analysis",
  "title_text": "Duration of Induced Hypothermia After Pediatric Cardiac Arrest: A Systematic Review and Network Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/690vh3wnfgrcq",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}