{
  "abstract": "Radioiodine (RAI) is a cornerstone of treatment for differentiated thyroid cancer (DTC), yet the immunological consequences of RAI-induced DNA damage remain poorly understood. Here, we examine cGAS–STING signaling as a potential mechanistic link between RAI-induced genotoxic stress and antitumor immunity. RAI delivers prolonged, thyroid-selective radiation to iodine-avid tumors, providing a plausible source of extranuclear DNA capable of engaging innate DNA sensing. We propose that transient RAI-associated cGAS–STING activation in DTC may favor IRF3–type I interferon-dependent immune priming, whereas persistent genomic stress in RAI-refractory anaplastic and poorly differentiated thyroid cancers (ATC/PDTC) may shift pathway output toward NF-κB-dominated, myeloid-suppressive programs. This acute-versus-chronic framework suggests that cGAS–STING dynamics could help define a therapeutic window for sequencing RAI with immune checkpoint blockade, while controlled STING activation may provide an alternative strategy for iodine-refractory disease. Direct evidence for RAI-induced cGAS–STING activation in thyroid tumors remains lacking, highlighting the need to define pathway kinetics across thyroid cancer subtypes and determine whether thyroid-specific endocrine signaling, including TSH–TSHR signaling, further modulates innate DNA sensing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Affiliated Hospital of Changchun University of Chinese Medicine , ,",
    "Patient Services Center, Affiliated Hospital of Changchun University of Chinese Medicine , ,",
    "Department of Endocrinology and Metabolism, Affiliated Hospital of Changchun University of Chinese Medicine , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Feng Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Daoming Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yan Luo"
    },
    {
      "affs": [
        2
      ],
      "name": "Chunhua Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/696a7ydkr6bp3.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1985864",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662556/?tool=EBI",
  "id": "696a7ydkr6bp3",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13662556",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Thyroid Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214955080",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662556/pdf/?tool=EBI",
  "pmcid": "PMC13662556",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/696a7ydkr6bp3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13662556",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13662556"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1985864",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1985864/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Thyroid Cancer Diagnosis and Treatment",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Radioiodine-induced cGAS-STING signaling and antitumor immunity in thyroid cancer",
  "title_text": "Radioiodine-induced cGAS-STING signaling and antitumor immunity in thyroid cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:15Z",
  "url": "https://research.draconitic.com/paper/696a7ydkr6bp3",
  "venue": "Frontiers in immunology",
  "versions": []
}