{
  "abstract": "Background\n\nThis study examines the association between prediabetes and nephropathy, focusing on chronic kidney disease and key indicators such as glomerular filtration rate and urinary albumin-to-creatinine ratio.Methods\n\nA systematic review of studies published before November 2024 included 26 articles, 15 cohort studies, and 11 cross-sectional studies, covering 350,546 individuals with normal glucose tolerance and 146,547 with prediabetes. A random-effects restricted maximum likelihood model was used to assess chronic kidney disease, glomerular filtration rate, and urinary albumin-to-creatinine ratio. The risk of chronic kidney disease was reported using relative risk (RR) with 95% confidence intervals, while mean difference (MD) was used for glomerular filtration rate and urinary albumin-to-creatinine ratio. Publication bias and methodological quality were assessed using the Egger regression test and the National Heart, Lung, and Blood Institute quality assessment tools. Sensitivity was tested using a leave-one-out method.Results\n\nData from 19 studies showed that individuals with prediabetes had a higher risk of developing chronic kidney disease (RR: 1.53; 95% CI: 1.30-1.81; P < 0.001), rising to 1.21 (95% CI: 1.78-2.73) when all three diagnostic methods were used. Across 31 observations, glomerular filtration rate declined by (MD: - 2.85; 95% CI: - 4.57 to - 1.13; P = 0.001). Urinary albumin-to-creatinine ratio increased in 21 observations (MD: 0.87; 95% CI: 0.19-1.55; P = 0.012). Stronger associations were observed in Asia than in Europe or the United States.Conclusion\n\nPrediabetes is linked to lower glomerular filtration rate and higher urinary albumin-to-creatinine ratio, indicating increased risk of chronic kidney disease. Early intervention may be beneficial.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.",
    "Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.",
    "Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.",
    "Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.",
    "Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. mrmaracy@yahoo.co.uk."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Raheleh Karimi"
    },
    {
      "affs": [
        0
      ],
      "name": "Roya Riahi"
    },
    {
      "affs": [
        1
      ],
      "name": "Mojgan Mortazavi"
    },
    {
      "affs": [
        2
      ],
      "name": "Setayesh Sindarreh"
    },
    {
      "affs": [
        3
      ],
      "name": "Ashraf Aminorroaya"
    },
    {
      "affs": [
        4
      ],
      "name": "Mohammad Reza Maracy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6987h0tqs0x12.bib",
  "cited_by": 0,
  "doi": "10.1186/s12882-026-05212-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13689277",
  "id": "6987h0tqs0x12",
  "issns": [
    "1471-2369"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907738",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC870-923"
    ],
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ]
  ],
  "openalex": "W7171025285",
  "pdf_url": "https://europepmc.org/articles/PMC13689277?pdf=render",
  "pmcid": "PMC13689277",
  "pmid": "42907738",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6987h0tqs0x12.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42907738",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907738"
    },
    {
      "first_seen": "2026-10-30T13:45:50Z",
      "native_id": "e7d9a88986004c13b0863bedac6034aa",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12882-026-05212-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Chronic Kidney Disease and Diabetes",
      "subfield": "general"
    }
  ],
  "title": "Association between prediabetes and nephropathy: a comprehensive systematic review and meta-analysis.",
  "title_text": "Association between prediabetes and nephropathy: a comprehensive systematic review and meta-analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:50Z",
  "url": "https://research.draconitic.com/paper/6987h0tqs0x12",
  "venue": "BMC nephrology",
  "versions": []
}