{
  "abstract": "Background: The PJI-TNM classification provides a multidimensional description of periprosthetic joint infection, but the prognostic contribution of its individual components remains uncertain. Objective: To evaluate component-specific associations with infection-related reoperation and determine how repeated surgical episodes within patients influence risk estimates. Methods: We retrospectively analysed 116 hip or knee periprosthetic joint infection surgical episodes in 84 patients treated from April 2016 to February 2026. The outcome was the first unplanned infection-related reoperation after each index operation. Kaplan-Meier and Cox analyses were performed, using patient-clustered robust variance estimates to account for repeated episodes. A patient-level sensitivity analysis used the first observed episode per patient. Results: Infection-related reoperation occurred after 42 episodes. Reoperation-free survival was 70.8% at 180 days, 63.1% at 1 year, and 55.1% at 2 years. In the primary clustered model, T2 showed an elevated but imprecise hazard estimate (hazard ratio 2.61, 95% confidence interval 0.89-7.72), whereas T1 did not. The N component showed no clear association with outcome. M2 produced a high estimate but comprised only three episodes from two patients. In the patient-level sensitivity analysis, the T2 hazard ratio was 4.78 (95% confidence interval 1.05-21.81). Conclusion: Prognostic information within PJI-TNM was unevenly distributed across components. Severe soft-tissue compromise represented by T2 showed the most consistent adverse signal, while repeated-episode analyses materially affected precision. Multicentre validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedic Surgery Kobe University Graduate School of Medicine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yohei Kumabe",
      "orcid": "0000-0003-2356-2930"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenichi Sawauchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yutaka Matsumiya"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomoaki Fukui"
    },
    {
      "affs": [
        0
      ],
      "name": "Shinya Hayashi"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomoyuki Matsumoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryosuke Kuroda"
    },
    {
      "affs": [
        0
      ],
      "name": "Keisuke Oe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69gb563gsgd5a.bib",
  "cited_by": 0,
  "doi": "10.52965/001c.172841",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723378/",
  "id": "69gb563gsgd5a",
  "issns": [
    "2035-8237",
    "2035-8164"
  ],
  "landing_url": "https://doi.org/10.52965/001c.172841",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "General"
    ],
    [
      "openalex",
      "2746|Orthopedic Infections and Treatments"
    ]
  ],
  "openalex": "W7224372112",
  "pdf_url": "https://orthopedicreviews.openmedicalpublishing.org/article/172841.pdf",
  "pmcid": "PMC13723378",
  "pmid": "42968709",
  "published": "2026-10-30",
  "publisher": "Open Medical Publishing",
  "ris": "https://research.draconitic.com/paper/69gb563gsgd5a.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:01Z",
      "native_id": "PMC13723378",
      "source": "pmc",
      "url": "https://doi.org/10.52965/001c.172841"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Orthopedic Infections and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Component-specific prognostic signals within a multidimensional classification for periprosthetic joint infection and the impact of repeated surgical episodes: a retrospective cohort study",
  "title_text": "Component-specific prognostic signals within a multidimensional classification for periprosthetic joint infection and the impact of repeated surgical episodes: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:13Z",
  "url": "https://research.draconitic.com/paper/69gb563gsgd5a",
  "venue": "Orthopedic Reviews",
  "versions": []
}