{
  "abstract": "Desulfovibrio spp. are associated with inflammatory diseases and human health, yet limited representative genomes and isolates hinder our understanding of their role in disease. Here, we assembled a comprehensive database of 2658 Desulfovibrio genomes across 90 diseases and 32 countries, including 24 human isolates. Genomic analyses showed extensive species diversity and revealed disease-associated functional traits, including flagellin and adaptation-associated genes (i.e., ureases). Flagellin-mediated Toll-like receptor 5 activation was species-specific and D. desulfuricans flagellin downregulated TGF-beta signalling in murine small intestinal organoids, suggesting impaired immune tolerance. Additionally, we investigated genomic capacity for hydrogen sulfide (H ₂ S) production, a main Desulfovibrio metabolite. While health- and disease-associated Desulfovibrio spp. mainly encoded dissimilatory sulfate reduction, tetrathionate metabolism-encoding bacteria were exclusively detected in inflammatory bowel diseases, including Proteus mirabilis and Morganella morganii . Overall, our study provides a comprehensive genomic Desulfovibrio resource and identifies new links associating strain variation, functional traits and H ₂ S-production with inflammatory diseases.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "Tingting Zheng"
    },
    {
      "name": "Isabel Keidel",
      "orcid": "0009-0000-9806-1087"
    },
    {
      "name": "Hélène Omer",
      "orcid": "0000-0002-4285-1386"
    },
    {
      "name": "Akshat Joshipura",
      "orcid": "0009-0003-5331-9007"
    },
    {
      "name": "Aurélie Cenier",
      "orcid": "0009-0000-3360-7181"
    },
    {
      "name": "Ezgi Atay",
      "orcid": "0000-0003-0208-4095"
    },
    {
      "name": "Yi Han Tan"
    },
    {
      "name": "Daniela Wetzel"
    },
    {
      "name": "Ranko Gacesa",
      "orcid": "0000-0003-2119-0539"
    },
    {
      "name": "Shijie Zhao"
    },
    {
      "name": "Claudia Mengoni",
      "orcid": "0000-0001-9629-2930"
    },
    {
      "name": "Shen Jin",
      "orcid": "0000-0001-5159-1187"
    },
    {
      "name": "Khoa Co"
    },
    {
      "name": "Carsten Peters",
      "orcid": "0000-0002-7193-499X"
    },
    {
      "name": "Nicola Segata",
      "orcid": "0000-0002-1583-5794"
    },
    {
      "name": "Ruth E. Ley",
      "orcid": "0000-0002-9087-1672"
    },
    {
      "name": "Monica Yabal"
    },
    {
      "name": "Rinse K. Weersma",
      "orcid": "0000-0001-7928-7371"
    },
    {
      "name": "Dirk Haller",
      "orcid": "0000-0002-6977-4085"
    },
    {
      "name": "Melanie Schirmer",
      "orcid": "0000-0001-6456-3679"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69mpp80vrc0cg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78314-1",
  "fulltext_url": null,
  "id": "69mpp80vrc0cg",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78314-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7221362678",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78314-1.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/69mpp80vrc0cg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:38Z",
      "native_id": "10.1038/s41467-026-78314-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78314-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Extensive genomic diversity in Desulfovibrio reveals species-specific functional traits associated with disease",
  "title_text": "Extensive genomic diversity in Desulfovibrio reveals species-specific functional traits associated with disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:38Z",
  "url": "https://research.draconitic.com/paper/69mpp80vrc0cg",
  "venue": "Nature Communications",
  "versions": []
}