{
  "abstract": "Glucose homeostasis depends on coordinated genetic and epigenetic regulation of pancreatic beta-cells, insulin-sensitive tissues, and neuroendocrine circuits. This review synthesises evidence from over 600 GWAS loci and the primary literature published between 2008 and 2026, and emerging single-cell functional genomics, CRISPR-based perturbation screens, deep-learning variant-effect predictors (DeepSEA, Enformer, AlphaGenome), and polygenic risk frameworks to explain insulin secretion, insulin signalling, and diabetes susceptibility, converting GWAS associations into mechanistic insight and genotype-guided precision therapies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry, All India Institute of Medical Sciences Rewari, Rewari, 123102 Haryana India",
    "Department of Biochemistry, All India Institute of Medical Sciences Jodhpur, Jodhpur, 342005 Rajasthan India"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Manoj Khokhar",
      "orcid": "0000-0001-7106-8545"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69p9108wfsgsn.bib",
  "cited_by": 0,
  "doi": "10.1038/s44324-026-00135-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710951/",
  "id": "69p9108wfsgsn",
  "issns": [
    "2948-2828"
  ],
  "landing_url": "https://doi.org/10.1038/s44324-026-00135-z",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1311|Genetic Associations and Epidemiology"
    ]
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  "openalex": "W7223710475",
  "pdf_url": "https://www.nature.com/articles/s44324-026-00135-z.pdf",
  "pmcid": "PMC13710951",
  "pmid": "42934248",
  "published": "2026-10-26",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/69p9108wfsgsn.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:49Z",
      "native_id": "PMC13710951",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s44324-026-00135-z"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic Associations and Epidemiology",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Multifaceted role of genetic and epigenetic architecture of glucose homeostasis and diabetes",
  "title_text": "Multifaceted role of genetic and epigenetic architecture of glucose homeostasis and diabetes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:49Z",
  "url": "https://research.draconitic.com/paper/69p9108wfsgsn",
  "venue": "npj Metabolic Health and Disease",
  "versions": []
}