{
  "abstract": "The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we show that the histone methyltransferase SUV39H1 plays an important role in human B lymphoid differentiation and that expression of SUV39H1 decreases with age in both human and mouse HSC, leading to a global reduction in H3K9 trimethylation and perturbed heterochromatin function. Further, we demonstrate that SUV39H1 is a target of microRNA miR-125b, a known regulator of HSC function, and that expression of miR-125b increases with age in human HSC. Overexpression of miR-125b and inhibition of SUV39H1 in young HSC induced loss of B cell potential. Conversely, both inhibition of miR-125 and enforced expression of SUV39H1 improved the capacity of HSC from elderly individuals to generate B cells. Our findings highlight the importance of heterochromatin regulation in HSC aging and B lymphopoiesis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Dounia Djeghloul"
    },
    {
      "name": "Klaudia Kuranda"
    },
    {
      "name": "Isabelle Kuzniak"
    },
    {
      "name": "Daniela Barbieri"
    },
    {
      "name": "Irina Naguibneva"
    },
    {
      "name": "Caroline Choisy"
    },
    {
      "name": "Jean-Christophe Bories"
    },
    {
      "name": "Christine Dosquet"
    },
    {
      "name": "Marika Pla"
    },
    {
      "name": "Valérie Vanneaux"
    },
    {
      "name": "Gérard Socié"
    },
    {
      "name": "Françoise Porteu"
    },
    {
      "name": "David Garrick"
    },
    {
      "name": "Michele Goodhardt"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69v67yc6d9ry1.bib",
  "cited_by": 122,
  "doi": "10.1016/j.stemcr.2016.05.007",
  "fulltext_url": null,
  "id": "69v67yc6d9ry1",
  "issns": [
    "2213-6711"
  ],
  "landing_url": "https://hal.science/hal-05830716v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W2431543454",
  "pdf_url": "http://www.cell.com/article/S2213671116300625/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/69v67yc6d9ry1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05830716",
      "source": "hal",
      "url": "https://hal.science/hal-05830716v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Pluripotent Stem Cells Research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation",
  "title_text": "Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/69v67yc6d9ry1",
  "venue": "Stem Cell Reports",
  "versions": []
}