{
  "abstract": "Objectives. Autoimmune hypothyroidism is associated with disturbances in lipid metabolism. This study assessed lipid profiles and cardiovascular risk markers in patients with overt (OH) and subclinical hypothyroidism (SH) compared with healthy controls, and examined lipid changes during levothyroxine treatment.\n\nMethods. This observational case–control study included 129 adults: 65 patients with autoimmune hypothyroidism (35 OH, 30 SH) and 64 controls. All patients had complete lipid, TSH, and fT4 measurements at baseline, 8 weeks, and 16 weeks. Lipid indices included LDL cholesterol (LDL-c), HDL cholesterol (HDL-c), non-HDL cholesterol (non-HDL-c), and the total cholesterol/HDL-c ratio. Between-group comparisons and paired longitudinal tests were performed; longitudinal p values were not adjusted for multiple comparisons.\n\nResults. Baseline LDL-c was higher in patients than controls (3.96 ± 1.67 vs 3.39 ± 0.76 mmol/L; p = 0.015). Non-HDL-c was higher in OH than SH (5.31 ± 2.19 vs 3.64 ± 0.96 mmol/L), and the total cholesterol/HDL-c ratio was higher in patients than controls (4.16 ± 1.59 vs 3.42 ± 0.75; p = 0.001). At 16 weeks, mean LDL-c decreased from 3.96 ± 1.67 to 3.28 ± 1.00 mmol/L (p = 0.001), and non-HDL-c from 4.54 ± 1.92 to 3.68 ± 1.17 mmol/L (p < 0.001). HDL-c did not improve significantly. At week 16, TSH was within the reference interval in 42 of 65 patients (64.6%).\n\nConclusions. Overt autoimmune hypothyroidism was associated with a more atherogenic lipid profile than SH or euthyroid status. During levothyroxine treatment, LDL-c and non-HDL-c improved, particularly in OH, while HDL-c did not. These observational findings do not establish a causal treatment effect or a reduction in cardiovascular events.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology, ”Nicolae Testemitanu” State University of Medicine and Pharmacy, Chisinau, Republic of Moldova",
    "Faculty of Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova",
    "Department of Endocrinology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Stela Vudu"
    },
    {
      "affs": [
        1
      ],
      "name": "Tishya Mukherjee"
    },
    {
      "affs": [
        2
      ],
      "name": "Larisa Zota"
    },
    {
      "affs": [
        2
      ],
      "name": "Lorina Vudu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69x595eym98s5.bib",
  "cited_by": 0,
  "doi": "10.5281/zenodo.23678641",
  "fulltext_url": "https://artamedica.md/artamedica/article/view/500",
  "id": "69x595eym98s5",
  "issns": [
    "1810-1852",
    "1810-1879"
  ],
  "landing_url": "https://doi.org/10.5281/zenodo.23678641",
  "language": "en",
  "licence": "CC-BY-SA",
  "licence_label": "CC BY-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "lcc",
      "RD1-811"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Association of Surgeons of the Republic of Moldova",
  "ris": "https://research.draconitic.com/paper/69x595eym98s5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:21:44Z",
      "native_id": "088e3f388cdf42149074f21762fb07e7",
      "source": "doaj",
      "url": "https://doi.org/10.5281/zenodo.23678641"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RD1-811",
      "subfield": "surgery"
    }
  ],
  "title": "LIPID PROFILE AND CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH AUTOIMMUNE HYPOTHYROIDISM",
  "title_text": "LIPID PROFILE AND CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH AUTOIMMUNE HYPOTHYROIDISM",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:21:44Z",
  "url": "https://research.draconitic.com/paper/69x595eym98s5",
  "venue": "Arta Medica",
  "versions": []
}