{
  "abstract": "Origanum sipyleum and Sideritis pisidica are endemic Turkish Lamiaceae species with previously reported phytochemistry and bioactivities, but matched-condition comparisons remain limited. This study aimed to compare aqueous extracts prepared by ultrasound-assisted extraction (5 g/100 mL water, 40 kHz, 360 W nominal ultrasonic power, 3 h, approximately 40 °C). A previously established 28-compound panel was analyzed by LC–MS/MS, alongside total phenolic and flavonoid contents, six antioxidant assays, and five enzyme-inhibitory assays. Eighteen and 19 phenolic compounds were detected in O. sipyleum and S. pisidica, respectively. Protocatechuic acid predominated in O. sipyleum (2334.15 µg/g extract), whereas chlorogenic acid predominated in S. pisidica (3525.31 µg/g extract). O. sipyleum exhibited significantly higher total phenolic and flavonoid contents and greater radical-scavenging and reducing activities, while phosphomolybdenum and ferrous-ion chelating activities were statistically comparable. Butyrylcholinesterase and α-amylase inhibitor-equivalent activities were statistically comparable between the species, whereas S. pisidica exhibited higher acetylcholinesterase-inhibitory (3.14 versus 2.94 mg galantamine equivalents/g extract) and tyrosinase-inhibitory activities (23.90 versus 21.01 mg kojic acid equivalents/g extract). O. sipyleum also displayed α-glucosidase inhibition (319.56 mg acarbose equivalents/g extract), while no inhibition was detected for S. pisidica within 0.1–5.0 mg/mL. This comparison identifies contrasting targeted phenolic profiles and assay-dependent in vitro responses without establishing compound-level causality.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Health Care Services, Atatürk Vocational School of Health Services, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ümmühan Ünlü"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/69zns2davzx4g.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213956",
  "fulltext_url": null,
  "id": "69zns2davzx4g",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3956",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/69zns2davzx4g.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:24:01Z",
      "native_id": "10.3390/molecules31213956",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3956"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "Ultrasound-Assisted Aqueous Extraction of Origanum sipyleum and Sideritis pisidica: LC–MS/MS Phenolic Profiles and Bioactivities",
  "title_text": "Ultrasound-Assisted Aqueous Extraction of Origanum sipyleum and Sideritis pisidica: LC–MS/MS Phenolic Profiles and Bioactivities",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:20:53Z",
  "url": "https://research.draconitic.com/paper/69zns2davzx4g",
  "venue": "Molecules",
  "versions": []
}